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Androgenicity and venous endothelial function in post-menopausal women
BACKGROUNDEndothelial dysfunction is one of the early signs of cardiovascular damage. High androgen levels have been related to inflammatory endothelial markers in pre- and post-menopausal women. AIMThis cross-sectional study aimed at investigating whether free androgen index (FAI) [estimated by div...
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| Published in: | Journal of endocrinological investigation 2010-04, Vol.33 (4), p.239-243 |
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| Language: | English |
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| container_start_page | 239 |
| container_title | Journal of endocrinological investigation |
| container_volume | 33 |
| creator | Maturana, M A Rubira, M C Consolim-Colombo, F Irigoyen, M C Spritzer, P M |
| description | BACKGROUNDEndothelial dysfunction is one of the early signs of cardiovascular damage. High androgen levels have been related to inflammatory endothelial markers in pre- and post-menopausal women. AIMThis cross-sectional study aimed at investigating whether free androgen index (FAI) [estimated by dividing total testosterone (nmol/l) by SHBG (nmol/l) x 100] is related to endothelial function during post-menopause. SUBJECTS AND METHODSTwenty-six post-menopausal women were assessed with the dorsal hand vein compliance technique. Acetylcholine (Ach) and sodium nitroprusside (SNP) dose-response curves were constructed to test endothelium-dependent and independent relaxation, respectively. RESULTSMean age was 54 yr (+/-4) and median time since menopause was 6 yr (interquartile range: 3-9). Patients were stratified according to FAI levels into two groups: FAI greater than or less than the group median of 2.5. Waist-to-hip ratio (WHR) was significantly higher in the group with FAI>2.5, as well as median dose of Ach for maximal vasodilation [720 (360-3600) ng/min with FAI>2.5 vs 36 (0.36-360) ng/min with FAI |
| doi_str_mv | 10.3275/6559 |
| format | article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_733560136</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733560136</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_7335601363</originalsourceid><addsrcrecordid>eNqNjEEKwjAUBYMgWK13yM5VNe0nSV2KWDyAewltqpH0pzaJ4u3NwgO4egwzPELykm2hknwnON_PSFbKihU11GJBlt4_GAMJtcxIc8BucjeNpjXhQxV29KXRRU81di7ctTXK0j5iG4xDapCOzodiSM2ook_u7RLkZN4r6_X6tyuyaU6X47kYJ_eM2ofrYHyrrVWo0_lVAnDBShDwf_kF2txBww</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733560136</pqid></control><display><type>article</type><title>Androgenicity and venous endothelial function in post-menopausal women</title><source>Springer Link</source><creator>Maturana, M A ; Rubira, M C ; Consolim-Colombo, F ; Irigoyen, M C ; Spritzer, P M</creator><creatorcontrib>Maturana, M A ; Rubira, M C ; Consolim-Colombo, F ; Irigoyen, M C ; Spritzer, P M</creatorcontrib><description>BACKGROUNDEndothelial dysfunction is one of the early signs of cardiovascular damage. High androgen levels have been related to inflammatory endothelial markers in pre- and post-menopausal women. AIMThis cross-sectional study aimed at investigating whether free androgen index (FAI) [estimated by dividing total testosterone (nmol/l) by SHBG (nmol/l) x 100] is related to endothelial function during post-menopause. SUBJECTS AND METHODSTwenty-six post-menopausal women were assessed with the dorsal hand vein compliance technique. Acetylcholine (Ach) and sodium nitroprusside (SNP) dose-response curves were constructed to test endothelium-dependent and independent relaxation, respectively. RESULTSMean age was 54 yr (+/-4) and median time since menopause was 6 yr (interquartile range: 3-9). Patients were stratified according to FAI levels into two groups: FAI greater than or less than the group median of 2.5. Waist-to-hip ratio (WHR) was significantly higher in the group with FAI>2.5, as well as median dose of Ach for maximal vasodilation [720 (360-3600) ng/min with FAI>2.5 vs 36 (0.36-360) ng/min with FAI<or=2.5; p=0.005]. Maximal vasodilation with SNP was similar in both groups. Positive correlations were observed between Ach doses and maximal vasodilation and FAI (r=0.473, p=0.015), waist (r=0.510, p= 0.011), and WHR (r=0.479, p=0.021). SHBG was negatively correlated with Ach doses (rs=-0.400, p=0.043). CONCLUSIONSThis study suggests that FAI, even within normal limits, is related to early changes in endothelial function in healthy post-menopausal women. Longitudinal studies are required to determine the clinical relevance of these findings.</description><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.3275/6559</identifier><language>eng</language><ispartof>Journal of endocrinological investigation, 2010-04, Vol.33 (4), p.239-243</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Maturana, M A</creatorcontrib><creatorcontrib>Rubira, M C</creatorcontrib><creatorcontrib>Consolim-Colombo, F</creatorcontrib><creatorcontrib>Irigoyen, M C</creatorcontrib><creatorcontrib>Spritzer, P M</creatorcontrib><title>Androgenicity and venous endothelial function in post-menopausal women</title><title>Journal of endocrinological investigation</title><description>BACKGROUNDEndothelial dysfunction is one of the early signs of cardiovascular damage. High androgen levels have been related to inflammatory endothelial markers in pre- and post-menopausal women. AIMThis cross-sectional study aimed at investigating whether free androgen index (FAI) [estimated by dividing total testosterone (nmol/l) by SHBG (nmol/l) x 100] is related to endothelial function during post-menopause. SUBJECTS AND METHODSTwenty-six post-menopausal women were assessed with the dorsal hand vein compliance technique. Acetylcholine (Ach) and sodium nitroprusside (SNP) dose-response curves were constructed to test endothelium-dependent and independent relaxation, respectively. RESULTSMean age was 54 yr (+/-4) and median time since menopause was 6 yr (interquartile range: 3-9). Patients were stratified according to FAI levels into two groups: FAI greater than or less than the group median of 2.5. Waist-to-hip ratio (WHR) was significantly higher in the group with FAI>2.5, as well as median dose of Ach for maximal vasodilation [720 (360-3600) ng/min with FAI>2.5 vs 36 (0.36-360) ng/min with FAI<or=2.5; p=0.005]. Maximal vasodilation with SNP was similar in both groups. Positive correlations were observed between Ach doses and maximal vasodilation and FAI (r=0.473, p=0.015), waist (r=0.510, p= 0.011), and WHR (r=0.479, p=0.021). SHBG was negatively correlated with Ach doses (rs=-0.400, p=0.043). CONCLUSIONSThis study suggests that FAI, even within normal limits, is related to early changes in endothelial function in healthy post-menopausal women. Longitudinal studies are required to determine the clinical relevance of these findings.</description><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqNjEEKwjAUBYMgWK13yM5VNe0nSV2KWDyAewltqpH0pzaJ4u3NwgO4egwzPELykm2hknwnON_PSFbKihU11GJBlt4_GAMJtcxIc8BucjeNpjXhQxV29KXRRU81di7ctTXK0j5iG4xDapCOzodiSM2ook_u7RLkZN4r6_X6tyuyaU6X47kYJ_eM2ofrYHyrrVWo0_lVAnDBShDwf_kF2txBww</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Maturana, M A</creator><creator>Rubira, M C</creator><creator>Consolim-Colombo, F</creator><creator>Irigoyen, M C</creator><creator>Spritzer, P M</creator><scope>7X8</scope></search><sort><creationdate>20100401</creationdate><title>Androgenicity and venous endothelial function in post-menopausal women</title><author>Maturana, M A ; Rubira, M C ; Consolim-Colombo, F ; Irigoyen, M C ; Spritzer, P M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_7335601363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maturana, M A</creatorcontrib><creatorcontrib>Rubira, M C</creatorcontrib><creatorcontrib>Consolim-Colombo, F</creatorcontrib><creatorcontrib>Irigoyen, M C</creatorcontrib><creatorcontrib>Spritzer, P M</creatorcontrib><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maturana, M A</au><au>Rubira, M C</au><au>Consolim-Colombo, F</au><au>Irigoyen, M C</au><au>Spritzer, P M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Androgenicity and venous endothelial function in post-menopausal women</atitle><jtitle>Journal of endocrinological investigation</jtitle><date>2010-04-01</date><risdate>2010</risdate><volume>33</volume><issue>4</issue><spage>239</spage><epage>243</epage><pages>239-243</pages><eissn>1720-8386</eissn><abstract>BACKGROUNDEndothelial dysfunction is one of the early signs of cardiovascular damage. High androgen levels have been related to inflammatory endothelial markers in pre- and post-menopausal women. AIMThis cross-sectional study aimed at investigating whether free androgen index (FAI) [estimated by dividing total testosterone (nmol/l) by SHBG (nmol/l) x 100] is related to endothelial function during post-menopause. SUBJECTS AND METHODSTwenty-six post-menopausal women were assessed with the dorsal hand vein compliance technique. Acetylcholine (Ach) and sodium nitroprusside (SNP) dose-response curves were constructed to test endothelium-dependent and independent relaxation, respectively. RESULTSMean age was 54 yr (+/-4) and median time since menopause was 6 yr (interquartile range: 3-9). Patients were stratified according to FAI levels into two groups: FAI greater than or less than the group median of 2.5. Waist-to-hip ratio (WHR) was significantly higher in the group with FAI>2.5, as well as median dose of Ach for maximal vasodilation [720 (360-3600) ng/min with FAI>2.5 vs 36 (0.36-360) ng/min with FAI<or=2.5; p=0.005]. Maximal vasodilation with SNP was similar in both groups. Positive correlations were observed between Ach doses and maximal vasodilation and FAI (r=0.473, p=0.015), waist (r=0.510, p= 0.011), and WHR (r=0.479, p=0.021). SHBG was negatively correlated with Ach doses (rs=-0.400, p=0.043). CONCLUSIONSThis study suggests that FAI, even within normal limits, is related to early changes in endothelial function in healthy post-menopausal women. Longitudinal studies are required to determine the clinical relevance of these findings.</abstract><doi>10.3275/6559</doi></addata></record> |
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| language | eng |
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| source | Springer Link |
| title | Androgenicity and venous endothelial function in post-menopausal women |
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