Extraction of monocrotaline from Crotalaria spectabilis using supercritical carbon dioxide and carbon dioxide-ethanol mixtures

Monocrotaline, a pyrrolizidine alkaloid of chemotherapeutic interest, was successfully extracted from the crushed seeds of Crotalaria spectabilis using supercritical carbon dioxide and ethanol mixtures. Overall solubilities of the plant material in the supercritical fluid phase were as high as 1.1 m...

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Bibliographic Details
Published in:Biotechnology and bioengineering 1989-12, Vol.34 (11), p.1357-1365
Main Authors: Schaeffer, Steven T., Zalkow, Leon H., Teja, Amyn S.
Format: Article
Language:English
Subjects:
alcaloide
alcaloides
alkaloids
Biological and medical sciences
Biotechnology
crotalaria
Fundamental and applied biological sciences. Psychology
General pharmacology
graine
Medical sciences
Methods. Procedures. Technologies
Others
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
seeds
semilla
Various methods and equipments
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Summary:Monocrotaline, a pyrrolizidine alkaloid of chemotherapeutic interest, was successfully extracted from the crushed seeds of Crotalaria spectabilis using supercritical carbon dioxide and ethanol mixtures. Overall solubilities of the plant material in the supercritical fluid phase were as high as 1.1 mass percent, and monocrotaline solubilities were as high as 0.07 mass percent. The solubility of monocrotaline in the presence of other plant material was smaller by 50 to 98% compared with the solubility of pure monocrotaline in the supercritical fluid. Also, it was found that the extraction of the complex plant material was time-dependent after approximately one percent of the original mass of the material had been extracted.
ISSN:0006-3592
1097-0290
DOI:10.1002/bit.260341103