Contralateral metachronous tumor occurrence is more frequently associated with distant metastases or postoperative intrarenal recurrence in renal cell carcinoma patients

• Published in: International journal of urology 2010-07, Vol.17 (7), p.615-622
• Main Authors: Amano, Hiroyuki, Kondo, Tsunenori, Hashimoto, Yasunobu, Kobayashi, Hirohito, Iizuka, Junpei, Shimada, Katsunori, Nakazawa, Hayakazu, Ito, Fumio, Tanabe, Kazunari
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell - epidemiology; Carcinoma, Renal Cell - pathology; Carcinoma, Renal Cell - secondary; Carcinoma, Renal Cell - surgery; Female; Humans; Kidney Neoplasms - epidemiology; Kidney Neoplasms - pathology; Kidney Neoplasms - secondary; Kidney Neoplasms - surgery; local neoplasm recurrences; Male; metachronous neoplasms; Middle Aged; multiple primary neoplasm; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - pathology; Neoplasms, Multiple Primary - epidemiology; Neoplasms, Multiple Primary - pathology; Prognosis; renal cell carcinoma; Retrospective Studies; survival; Survival Rate; Young Adult
• ISSN: 0919-8172; 1442-2042
• DOI: 10.1111/j.1442-2042.2010.02541.x

Objective:  To analyze the prognosis of patients with sporadic bilateral renal cell carcinoma (RCC). Methods:  From January 1979 to December 2007, 984 patients with sporadic RCC underwent surgery at our department. Of these, 53 patients (5.7%) presenting with bilateral RCC were included in this retrospective analysis. Results:  Thirty‐one of the 53 bilateral RCC patients had synchronous RCC, and 22 had metachronous RCC. Distant metastases by the time of the bilateral tumor occurrence were found in four patients (13%) in the synchronous group and in 10 patients (48%) in the metachronous group. No difference was found between the two groups in terms of overall survival. In contrast, survival after the second surgery in the metachronous group was significantly lower than that after the first surgery (P