Evaluation of antioxidant and anti-atherogenic properties of Glycyrrhiza glabra root using in vitro models

The aim of present study was to evaluate antioxidant property of Glycyrrhiza glabra root extracts using in vitro models. The dose-dependent aqueous and ethanolic extracts demonstrated the scavenging activity against nitric oxide (concentration that caused 50% inhibition of nitric oxide radicals [IC5...

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Bibliographic Details
Published in:International journal of food sciences and nutrition 2009-01, Vol.60 (S2), p.135-149
Main Authors: Visavadiya, Nishant P., Soni, Badrish, Dalwadi, Nirav
Format: Article
Language:English
Subjects:
Anti-atherogenic
antioxidant
Antioxidants
Antioxidants - analysis
Antioxidants - pharmacology
Atherosclerosis - prevention & control
Cardiovascular Agents - analysis
Cardiovascular Agents - pharmacology
Chelating Agents - analysis
Chelating Agents - pharmacology
Copper - chemistry
Dose-Response Relationship, Drug
Flowers & plants
Food science
Free Radical Scavengers - analysis
Free Radical Scavengers - pharmacology
Glycyrrhiza - chemistry
Glycyrrhiza glabra
Inhibitory Concentration 50
Iron - chemistry
lipid peroxidation
Lipid Peroxidation - drug effects
Lipoproteins, LDL - blood
low-density lipoprotein
Mitochondria - drug effects
Mitochondria - metabolism
Nitric oxide
Oxidation
Oxidation-Reduction
Plant Extracts - pharmacology
Plant Roots - chemistry
Studies
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:The aim of present study was to evaluate antioxidant property of Glycyrrhiza glabra root extracts using in vitro models. The dose-dependent aqueous and ethanolic extracts demonstrated the scavenging activity against nitric oxide (concentration that caused 50% inhibition of nitric oxide radicals [IC50]=72 and 62.1 µg/ml, respectively), superoxide (IC50=64.2 and 38.4 µg/ml, respectively), hydroxyl (IC50=81.9 and 63 µg/ml, respectively), DPPH (IC50=43.6 and 28.3 µg/ml, respectively) and ABTS*+ (IC50=77.3 and 57.2 µg/ml, respectively) radicals. Further, both extracts showed strong reducing power and iron-chelating capacities. In the Fe2+/ascorbate system, both extracts were found to inhibit mitochondrial fraction lipid peroxidation. In copper-catalyzed human serum and low-density lipoprotein oxidation models, both extracts significantly (P
ISSN:0963-7486
1465-3478
DOI:10.1080/09637480902877998