Effects of the administration of beta-blockers on ventricular remodeling induced by cigarette smoking in rats

The role of the adrenergic system on ventricular remodeling induced by cigarette smoking is unknown. To investigate the influence of propranolol on ventricular remodeling induced by exposure to tobacco smoke. Rats were divided into three groups: 1) C, n=10--control group; 2) F, n=10--animals exposed...

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Published in:Arquivos brasileiros de cardiologia 2009-06, Vol.92 (6), p.443-483
Main Authors: Duarte, Daniella R, Oliveira, Lucienne C, Minicucci, Marcos F, Azevedo, Paula S, Matsubara, Beatriz B, Matsubara, Luiz S, Campana, Alvaro O, Paiva, Sergio A R, Zornoff, Leonardo A M
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - pharmacology
Animals
Inhalation Exposure - adverse effects
Male
Models, Animal
Propranolol - pharmacology
Rats
Rats, Wistar
Tobacco Smoke Pollution - adverse effects
Ventricular Dysfunction, Left - drug therapy
Ventricular Dysfunction, Left - etiology
Ventricular Dysfunction, Left - pathology
Ventricular Remodeling - drug effects
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Summary:The role of the adrenergic system on ventricular remodeling induced by cigarette smoking is unknown. To investigate the influence of propranolol on ventricular remodeling induced by exposure to tobacco smoke. Rats were divided into three groups: 1) C, n=10--control group; 2) F, n=10--animals exposed to tobacco smoke; 3) BB, n=10--animals receiving propranolol and exposed to tobacco smoke (40 mg/kg/day). After 2 months, the animals underwent echocardiographic and morphometric analyses. One-way ANOVA (mean +/- standard deviation) or the Kruskal-Wallis test (median and interquartile interval) was used. Group BB showed a lower heart rate than group F (C = 358 +/- 74 bpm, F = 374 +/- 53 bpm, BB = 297 +/- 30; P = 0.02). Group F showed greater end-diastolic diameters (C = 18.6 +/- 3.4 mm/kg, F = 22.8 +/- 1.8 mm/kg, BB = 21.7 +/- 1.8 mm/kg; P = 0.003) and left ventricular (LV) end-systolic diameters (C = 8.6 +/- 2.1 mm/kg, F = 11.3 +/- 1.3 mm/kg, BB = 9.9 +/- 1.2 mm/kg; P = 0.004), adjusted for body weight (BW) and a tendency towards a lower ejection fraction (C = 0.90 +/- 0.03, F = 0.87 +/- 0.03, BB =0.90 +/- 0.02; P = 0.07) than group C. Group BB showed a tendency towards a lower LV/BW ratio than group F (C = 1.94 (1.87 - 1.97), F = 2.03 (1.9-2.1) mg/g, BB = 1.89 (1.86-1.94); P = 0.09). Administration of propranolol attenuated some of the variables of ventricular remodeling induced by the exposure to tobacco smoke in rats.
ISSN:1678-4170