Coronary aneurysm associated with coronary perforation after sirolimus-eluting stents implantation: Close follow-up exceeding 2 years by coronary 3-dimensional computed tomography

• Published in: Journal of cardiology 2009-08, Vol.54 (1), p.115-120
• Main Authors: Eshima, Ken-ichi, MD, Takemoto, Masao, MD, Inoue, Shujiro, MD, Higo, Taiki, MD, Tada, Hideo, MD, Sunagawa, Kenji, MD
• Format: Article
• Language: English
• Subjects: 3-Dimensional computed tomography; Aged; Cardiovascular; Coronary aneurysm; Coronary Aneurysm - diagnostic imaging; Coronary Aneurysm - etiology; Coronary Angiography; Coronary perforation; Coronary Vessels - injuries; Drug-Eluting Stents - adverse effects; Female; Follow-Up Studies; Humans; Imaging, Three-Dimensional; Percutaneous coronary intervention; Silorimus-eluting stent; Sirolimus - administration & dosage; Tomography, X-Ray Computed
• ISSN: 0914-5087; 1876-4738
• DOI: 10.1016/j.jjcc.2008.09.013

Summary Both coronary perforation and aneurysms associated with sirolimus-eluting stent (SES) implantations are uncommon complications. We describe an unusual case of a coronary aneurysm associated with a coronary perforation after SES implantation. Although their pathogenesis has not yet been completely elucidated, some technical factors including the use of excessive pressure during the stent deployment, and sirolimus-induced vascular inflammatory reactions and poor healing response at the perforation site may be related to the shape of the aneurismal formation. Fortunately and interestingly, the size of the coronary aneurysm gradually decreased, and finally by 26 months a nearly complete resolution of the aneurysm had taken place. Furthermore, close follow-up by coronary 3-dimensional computed tomography (3DCT) could clearly demonstrate the natural course of this aneurysm. To the best of our knowledge, there have been no reports on the natural course of coronary aneurysm associated with a coronary perforation after SES(s) implantation for more than 2 years using coronary 3DCT as in this present case. The phenomenon of the spontaneous resolution of the coronary aneurysm after SES implantation may have clinical therapeutic implications.