The discovery of genes implicated in myocardial infarction

The era of Genome‐Wide Association Studies (GWAS) commenced in 2007 with the study of the Wellcome Trust Case Control Consortium (WTCCC) which for the first time ever showed that risk loci can be identified by scanning the complete genome for sequence variation in large numbers of cases of disease a...

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2009-07, Vol.7, p.305-307
Main Author: OUWEHAND, W. H.
Format: Article
Language:English
Subjects:
Coronary Artery Disease - genetics
Genetic Predisposition to Disease
genetics
Genome-Wide Association Study
Humans
myocardial infarction
Myocardial Infarction - genetics
platelets
Quantitative Trait Loci
quantitative traits
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Summary:The era of Genome‐Wide Association Studies (GWAS) commenced in 2007 with the study of the Wellcome Trust Case Control Consortium (WTCCC) which for the first time ever showed that risk loci can be identified by scanning the complete genome for sequence variation in large numbers of cases of disease and healthy controls. We and others have expanded on this effort and successfully identified the first 11 risk loci for myocardial infarction (MI) and coronary artery disease (CAD). Studies on quantitative traits provide an alternative approach to identify MI/CAD risk loci. This review captures the early successes in the emerging field of disease genomics.
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/j.1538-7836.2009.03441.x