Evaluation of carboplatin dosage based on 4-variable modification of diet in renal disease equation

Background Traditionally, carboplatin dosage is based on the Calvert formula. Glomerular filtration rate (GFR) and creatinine clearance (CrCl) are often used interchangeably in this formula. The modification of diet in renal disease (MDRD) equation is now routinely available to estimate GFR (eGFR)....

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Bibliographic Details
Published in:Irish journal of medical science 2009-09, Vol.178 (3), p.301-307
Main Authors: Barry, A., O’Cearbhaill, R., Griffin, D., Donnellan, P., Keane, M., Grimes, H.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Carboplatin - administration & dosage
Carboplatin - therapeutic use
Creatinine
Diet
Family Medicine
Female
General Practice
Glomerular Filtration Rate
Humans
Internal Medicine
Kidney Diseases
Male
Medicine
Medicine & Public Health
Middle Aged
Nutritional Status
Original Article
Retrospective Studies
Statistics as Topic
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Summary:Background Traditionally, carboplatin dosage is based on the Calvert formula. Glomerular filtration rate (GFR) and creatinine clearance (CrCl) are often used interchangeably in this formula. The modification of diet in renal disease (MDRD) equation is now routinely available to estimate GFR (eGFR). Methods We performed a retrospective analysis of carboplatin dosage in our institute. Calvert formula derived carboplatin dose using eGFR calculated from the MDRD equation was compared to estimated CrCl from the Cockcroft-Gault and Jelliffe equations. Results Ninety-two carboplatin treatment episodes were recorded. eGFR and CrCl correlated reasonably well with a correlation coefficient ( r ) of 0.88. The correlation was weakest at lower levels of serum creatinine. Correcting eGFR for body surface area resulted in a tighter correlation ( r  = 0.94). Conclusion The MDRD derived eGFR is readily available and may prove very useful in calculating carboplatin dosage for patients with impaired renal function.
ISSN:0021-1265
1863-4362
DOI:10.1007/s11845-008-0250-z