Nosocomial candidemia at a general hospital: The change of epidemiological and clinical characteristics. A comparative study of 2 cohorts (1993–1998 versus 2002–2005)

AbstractBackgroundNosocomial candidemia (NC) is associated with high mortality, increased hospital stay and greater economical cost.AimsTo evaluate epidemiological and clinical aspects of 2 different cohorts of non-paediatric patients with NC.MethodsA retrospective observational and comparative stud...

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Published in:Revista iberoamericana de micología 2009-09, Vol.26 (3), p.184-188
Main Authors: Gómez, Joaquín, García-Vázquez, Elisa, Espinosa, Cristina, Ruiz, Joaquín, Canteras, Manuel, Hernández-Torres, Alicia, Baños, Victor, Herrero, José Antonio, Valdés, Mariano
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Candida spp
Candidemia
Candidiasis - diagnosis
Candidiasis - epidemiology
Cohort Studies
Cross Infection - diagnosis
Cross Infection - epidemiology
Epidemiology
Epidemiología
Female
Fungemia - diagnosis
Fungemia - epidemiology
Hospitals, General
Humans
Infectious Disease
Male
Middle Aged
Nosocomial
Retrospective Studies
Young Adult
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container_title Revista iberoamericana de micología
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creator Gómez, Joaquín
García-Vázquez, Elisa
Espinosa, Cristina
Ruiz, Joaquín
Canteras, Manuel
Hernández-Torres, Alicia
Baños, Victor
Herrero, José Antonio
Valdés, Mariano
description AbstractBackgroundNosocomial candidemia (NC) is associated with high mortality, increased hospital stay and greater economical cost.AimsTo evaluate epidemiological and clinical aspects of 2 different cohorts of non-paediatric patients with NC.MethodsA retrospective observational and comparative study of patients with NC. Patients were identified by review of results of blood cultures from the hospital microbiology laboratory. We analysed epidemiological, clinical, microbiological and laboratory data and changes in the 2 cohorts: 1993–1998 (P1) and from 2002 to 2005 (P2).ResultsEighty patients were studied during P1 and 107 during P2; incidence was 9/10,000 in P1 and 15.8/10,000 admitted patients in P2 ( p
doi_str_mv 10.1016/j.riam.2009.02.003
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A comparative study of 2 cohorts (1993–1998 versus 2002–2005)</title><source>ScienceDirect Journals</source><creator>Gómez, Joaquín ; García-Vázquez, Elisa ; Espinosa, Cristina ; Ruiz, Joaquín ; Canteras, Manuel ; Hernández-Torres, Alicia ; Baños, Victor ; Herrero, José Antonio ; Valdés, Mariano</creator><creatorcontrib>Gómez, Joaquín ; García-Vázquez, Elisa ; Espinosa, Cristina ; Ruiz, Joaquín ; Canteras, Manuel ; Hernández-Torres, Alicia ; Baños, Victor ; Herrero, José Antonio ; Valdés, Mariano</creatorcontrib><description><![CDATA[AbstractBackgroundNosocomial candidemia (NC) is associated with high mortality, increased hospital stay and greater economical cost.AimsTo evaluate epidemiological and clinical aspects of 2 different cohorts of non-paediatric patients with NC.MethodsA retrospective observational and comparative study of patients with NC. Patients were identified by review of results of blood cultures from the hospital microbiology laboratory. We analysed epidemiological, clinical, microbiological and laboratory data and changes in the 2 cohorts: 1993–1998 (P1) and from 2002 to 2005 (P2).ResultsEighty patients were studied during P1 and 107 during P2; incidence was 9/10,000 in P1 and 15.8/10,000 admitted patients in P2 ( p<0.05). Mean age was 52 years in P1 and 61 years in P2 ( p<0.05); 66% and 49% NC were due to Candida albicans in P1 and P2, respectively ( p<0.05); diabetes was present in 12% in P1 and in 25% in P2 ( p<0.05). All of the patients had previously received at least one course of broad-spectrum antibiotics. A statistically significant difference ( p<0.05) in predisposing conditions was identified in central intravenous line rate (100% in P1 and 91% in P2) and previous surgery (43% in P1 and 78% in P2). Acute severity of illness at onset and complications were more frequent in P2 ( p<0.05). Mortality rate was similar in P1 and P2 (51% and 49.5%, respectively). ConclusionsFrequency of NC has increased and non- albicans Candida is now more frequent than C. albicans. Although acute severity of illness at onset and complications are now more frequent, mortality remains the same.]]></description><identifier>ISSN: 1130-1406</identifier><identifier>DOI: 10.1016/j.riam.2009.02.003</identifier><identifier>PMID: 19635438</identifier><language>eng</language><publisher>Spain: Elsevier Espana</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Candida spp ; Candidemia ; Candidiasis - diagnosis ; Candidiasis - epidemiology ; Cohort Studies ; Cross Infection - diagnosis ; Cross Infection - epidemiology ; Epidemiology ; Epidemiología ; Female ; Fungemia - diagnosis ; Fungemia - epidemiology ; Hospitals, General ; Humans ; Infectious Disease ; Male ; Middle Aged ; Nosocomial ; Retrospective Studies ; Young Adult</subject><ispartof>Revista iberoamericana de micología, 2009-09, Vol.26 (3), p.184-188</ispartof><rights>Revista Iberoamericana de Micología</rights><rights>2009 Revista Iberoamericana de Micología</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-2f310e8fcde5ba5ed4386b467317ed4a5bb3127572802972695d83429dcb63573</citedby><cites>FETCH-LOGICAL-c410t-2f310e8fcde5ba5ed4386b467317ed4a5bb3127572802972695d83429dcb63573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19635438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gómez, Joaquín</creatorcontrib><creatorcontrib>García-Vázquez, Elisa</creatorcontrib><creatorcontrib>Espinosa, Cristina</creatorcontrib><creatorcontrib>Ruiz, Joaquín</creatorcontrib><creatorcontrib>Canteras, Manuel</creatorcontrib><creatorcontrib>Hernández-Torres, Alicia</creatorcontrib><creatorcontrib>Baños, Victor</creatorcontrib><creatorcontrib>Herrero, José Antonio</creatorcontrib><creatorcontrib>Valdés, Mariano</creatorcontrib><title>Nosocomial candidemia at a general hospital: The change of epidemiological and clinical characteristics. A comparative study of 2 cohorts (1993–1998 versus 2002–2005)</title><title>Revista iberoamericana de micología</title><addtitle>Rev Iberoam Micol</addtitle><description><![CDATA[AbstractBackgroundNosocomial candidemia (NC) is associated with high mortality, increased hospital stay and greater economical cost.AimsTo evaluate epidemiological and clinical aspects of 2 different cohorts of non-paediatric patients with NC.MethodsA retrospective observational and comparative study of patients with NC. Patients were identified by review of results of blood cultures from the hospital microbiology laboratory. We analysed epidemiological, clinical, microbiological and laboratory data and changes in the 2 cohorts: 1993–1998 (P1) and from 2002 to 2005 (P2).ResultsEighty patients were studied during P1 and 107 during P2; incidence was 9/10,000 in P1 and 15.8/10,000 admitted patients in P2 ( p<0.05). Mean age was 52 years in P1 and 61 years in P2 ( p<0.05); 66% and 49% NC were due to Candida albicans in P1 and P2, respectively ( p<0.05); diabetes was present in 12% in P1 and in 25% in P2 ( p<0.05). All of the patients had previously received at least one course of broad-spectrum antibiotics. A statistically significant difference ( p<0.05) in predisposing conditions was identified in central intravenous line rate (100% in P1 and 91% in P2) and previous surgery (43% in P1 and 78% in P2). Acute severity of illness at onset and complications were more frequent in P2 ( p<0.05). Mortality rate was similar in P1 and P2 (51% and 49.5%, respectively). ConclusionsFrequency of NC has increased and non- albicans Candida is now more frequent than C. albicans. Although acute severity of illness at onset and complications are now more frequent, mortality remains the same.]]></description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Candida spp</subject><subject>Candidemia</subject><subject>Candidiasis - diagnosis</subject><subject>Candidiasis - epidemiology</subject><subject>Cohort Studies</subject><subject>Cross Infection - diagnosis</subject><subject>Cross Infection - epidemiology</subject><subject>Epidemiology</subject><subject>Epidemiología</subject><subject>Female</subject><subject>Fungemia - diagnosis</subject><subject>Fungemia - epidemiology</subject><subject>Hospitals, General</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nosocomial</subject><subject>Retrospective Studies</subject><subject>Young Adult</subject><issn>1130-1406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9UsuO1DAQzAHELgs_wAH5BhwmtO08EVppteIlreDAcrYcuzPjIYkH2xlpbvwDf8Fn8SV0dgYhccCXdpeqyuouZ9kTDjkHXr3c5sHpMRcAbQ4iB5D3snPOJax4AdVZ9jDGLYCogPMH2RlvK1kWsjnPfn700Rs_Oj0woyfrLNKd6cQ0W-OEgfCNjzuX9PCK3W6QmY2e1sh8z3B3x_aDXztDPJIzM7jpriFa0CZhcDE5E3N2xeiZHYHJ7ZHFNNvDYiII3viQInvO21b--v6DSsP2GOIcGc0jCKJSvniU3e_1EPHxqV5kX96-ub1-v7r59O7D9dXNyhQc0kr0kgM2vbFYdrpES3NWXVHVktfU6LLrJBd1WYsGRFuLqi1tIwvRWtPRVmp5kT07-u6C_zZjTGp00eAw6An9HFUtiVXVvCWmODJN8DEG7NUuuFGHg-KglljUVi2xqCUWBUJRLCR6erKfuxHtX8kpEyK8PhKQhtw7DCoah5NB6wKapKx3__e__Ef-J5OveMC49XOYaH2Kq0gC9Xn5JMsfgRboFLX8DdTmtc4</recordid><startdate>20090930</startdate><enddate>20090930</enddate><creator>Gómez, Joaquín</creator><creator>García-Vázquez, Elisa</creator><creator>Espinosa, Cristina</creator><creator>Ruiz, Joaquín</creator><creator>Canteras, Manuel</creator><creator>Hernández-Torres, Alicia</creator><creator>Baños, Victor</creator><creator>Herrero, José Antonio</creator><creator>Valdés, Mariano</creator><general>Elsevier Espana</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090930</creationdate><title>Nosocomial candidemia at a general hospital: The change of epidemiological and clinical characteristics. A comparative study of 2 cohorts (1993–1998 versus 2002–2005)</title><author>Gómez, Joaquín ; García-Vázquez, Elisa ; Espinosa, Cristina ; Ruiz, Joaquín ; Canteras, Manuel ; Hernández-Torres, Alicia ; Baños, Victor ; Herrero, José Antonio ; Valdés, Mariano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-2f310e8fcde5ba5ed4386b467317ed4a5bb3127572802972695d83429dcb63573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Candida spp</topic><topic>Candidemia</topic><topic>Candidiasis - diagnosis</topic><topic>Candidiasis - epidemiology</topic><topic>Cohort Studies</topic><topic>Cross Infection - diagnosis</topic><topic>Cross Infection - epidemiology</topic><topic>Epidemiology</topic><topic>Epidemiología</topic><topic>Female</topic><topic>Fungemia - diagnosis</topic><topic>Fungemia - epidemiology</topic><topic>Hospitals, General</topic><topic>Humans</topic><topic>Infectious Disease</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nosocomial</topic><topic>Retrospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gómez, Joaquín</creatorcontrib><creatorcontrib>García-Vázquez, Elisa</creatorcontrib><creatorcontrib>Espinosa, Cristina</creatorcontrib><creatorcontrib>Ruiz, Joaquín</creatorcontrib><creatorcontrib>Canteras, Manuel</creatorcontrib><creatorcontrib>Hernández-Torres, Alicia</creatorcontrib><creatorcontrib>Baños, Victor</creatorcontrib><creatorcontrib>Herrero, José Antonio</creatorcontrib><creatorcontrib>Valdés, Mariano</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Revista iberoamericana de micología</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gómez, Joaquín</au><au>García-Vázquez, Elisa</au><au>Espinosa, Cristina</au><au>Ruiz, Joaquín</au><au>Canteras, Manuel</au><au>Hernández-Torres, Alicia</au><au>Baños, Victor</au><au>Herrero, José Antonio</au><au>Valdés, Mariano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nosocomial candidemia at a general hospital: The change of epidemiological and clinical characteristics. A comparative study of 2 cohorts (1993–1998 versus 2002–2005)</atitle><jtitle>Revista iberoamericana de micología</jtitle><addtitle>Rev Iberoam Micol</addtitle><date>2009-09-30</date><risdate>2009</risdate><volume>26</volume><issue>3</issue><spage>184</spage><epage>188</epage><pages>184-188</pages><issn>1130-1406</issn><abstract><![CDATA[AbstractBackgroundNosocomial candidemia (NC) is associated with high mortality, increased hospital stay and greater economical cost.AimsTo evaluate epidemiological and clinical aspects of 2 different cohorts of non-paediatric patients with NC.MethodsA retrospective observational and comparative study of patients with NC. Patients were identified by review of results of blood cultures from the hospital microbiology laboratory. We analysed epidemiological, clinical, microbiological and laboratory data and changes in the 2 cohorts: 1993–1998 (P1) and from 2002 to 2005 (P2).ResultsEighty patients were studied during P1 and 107 during P2; incidence was 9/10,000 in P1 and 15.8/10,000 admitted patients in P2 ( p<0.05). Mean age was 52 years in P1 and 61 years in P2 ( p<0.05); 66% and 49% NC were due to Candida albicans in P1 and P2, respectively ( p<0.05); diabetes was present in 12% in P1 and in 25% in P2 ( p<0.05). All of the patients had previously received at least one course of broad-spectrum antibiotics. A statistically significant difference ( p<0.05) in predisposing conditions was identified in central intravenous line rate (100% in P1 and 91% in P2) and previous surgery (43% in P1 and 78% in P2). Acute severity of illness at onset and complications were more frequent in P2 ( p<0.05). Mortality rate was similar in P1 and P2 (51% and 49.5%, respectively). ConclusionsFrequency of NC has increased and non- albicans Candida is now more frequent than C. albicans. Although acute severity of illness at onset and complications are now more frequent, mortality remains the same.]]></abstract><cop>Spain</cop><pub>Elsevier Espana</pub><pmid>19635438</pmid><doi>10.1016/j.riam.2009.02.003</doi><tpages>5</tpages></addata></record>
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source ScienceDirect Journals
subjects Adolescent
Adult
Aged
Aged, 80 and over
Candida spp
Candidemia
Candidiasis - diagnosis
Candidiasis - epidemiology
Cohort Studies
Cross Infection - diagnosis
Cross Infection - epidemiology
Epidemiology
Epidemiología
Female
Fungemia - diagnosis
Fungemia - epidemiology
Hospitals, General
Humans
Infectious Disease
Male
Middle Aged
Nosocomial
Retrospective Studies
Young Adult
title Nosocomial candidemia at a general hospital: The change of epidemiological and clinical characteristics. A comparative study of 2 cohorts (1993–1998 versus 2002–2005)
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