Pulmonary manifestations of light chain deposition disease

ABSTRACT Light chain deposition disease (LCDD) is a rare condition characterized by extracellular light chain deposition in tissues. Patients commonly have an underlying plasma cell dyscrasia, and produce excess levels of monoclonal light chains. Renal involvement is the most common clinical manifes...

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Bibliographic Details
Published in:Respirology (Carlton, Vic.) Vic.), 2009-07, Vol.14 (5), p.767-770
Main Authors: RHO, Lisa, QIU, Libo, STRAUCHEN, James A., GORDON, Ronald E., TEIRSTEIN, Alvin S.
Format: Article
Language:English
Subjects:
Adult
Aged, 80 and over
Biopsy
Female
Humans
Immunoglobulin Light Chains - metabolism
kappa‐immunoglobulin light chain
lambda‐immunoglobulin light chain
light chain deposition disease
Lung - immunology
Lung - pathology
Lung Diseases - diagnosis
Lung Diseases - etiology
Lung Diseases - immunology
Male
Middle Aged
non‐amyloid
Paraproteinemias - complications
pulmonary nodule
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Summary:ABSTRACT Light chain deposition disease (LCDD) is a rare condition characterized by extracellular light chain deposition in tissues. Patients commonly have an underlying plasma cell dyscrasia, and produce excess levels of monoclonal light chains. Renal involvement is the most common clinical manifestation. Rarely, light chains are deposited in the lung. We present the pathologic and radiographic findings of three patients with biopsy‐proven pulmonary light chain disease and a review of the literature.
ISSN:1323-7799
1440-1843
DOI:10.1111/j.1440-1843.2009.01560.x