Multiple-Organocatalyst-Promoted Cascade Reaction: A Fast and Efficient Entry into Fully Substituted Piperidines

Multiple reactions in a single pot: The development of a catalytic asymmetric approach to fully substituted piperidines, which previously remained elusive, is achieved by the use of a multi‐catalyst‐promoted cascade reaction (see scheme). The one‐pot reaction cascade is easy to perform, highly stere...

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Bibliographic Details
Published in:Chemistry : a European journal 2010-04, Vol.16 (13), p.3922-3925
Main Authors: Wang, Yao, Yu, De-Feng, Liu, Yao-Zong, Wei, Hao, Luo, Yong-Chun, Dixon, Darren J., Xu, Peng-Fei
Format: Article
Language:English
Subjects:
asymmetric catalysis
Asymmetry
Cascade chemical reactions
Cascades
Catalysis
Catalysts
Chemistry
Cyclization
domino reactions
enantioselectivity
Molecular Structure
organocatalysis
Piperidine
piperidines
Piperidines - chemistry
Reaction products
Stereoisomerism
Transformations
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Summary:Multiple reactions in a single pot: The development of a catalytic asymmetric approach to fully substituted piperidines, which previously remained elusive, is achieved by the use of a multi‐catalyst‐promoted cascade reaction (see scheme). The one‐pot reaction cascade is easy to perform, highly stereoselective and broad in scope, and the reaction products are high‐value intermediates for multiple synthetic transformations.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201000059