Beyond low-density lipoprotein cholesterol: respective contributions of non-high-density lipoprotein cholesterol levels, triglycerides, and the total cholesterol/high-density lipoprotein cholesterol ratio to coronary heart disease risk in apparently healthy men and women

This study was designed to test the hypothesis that at any low-density lipoprotein cholesterol (LDL-C) level, other lipid parameters such as non-high-density lipoprotein cholesterol (HDL-C) levels, triglyceride (TG) levels, and the total cholesterol (TC)/HDL-C are still associated with an increased...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2009-12, Vol.55 (1), p.35-41
Main Authors: Arsenault, Benoit J, Rana, Jamal S, Stroes, Erik S G, Després, Jean-Pierre, Shah, Prediman K, Kastelein, John J P, Wareham, Nicholas J, Boekholdt, S Matthijs, Khaw, Kay-Tee
Format: Article
Language:English
Subjects:
Aged
Cardiology
Cardiovascular disease
Cholesterol
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Coronary Disease - blood
Coronary Disease - epidemiology
England - epidemiology
Female
Heart attacks
Hormone replacement therapy
Humans
Male
Middle Aged
Older people
Prospective Studies
Risk Factors
Triglycerides - blood
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Summary:This study was designed to test the hypothesis that at any low-density lipoprotein cholesterol (LDL-C) level, other lipid parameters such as non-high-density lipoprotein cholesterol (HDL-C) levels, triglyceride (TG) levels, and the total cholesterol (TC)/HDL-C are still associated with an increased coronary heart disease (CHD) risk. Although LDL-C is considered to be the primary target of lipid-lowering therapy, other parameters of the lipoprotein-lipid profile may more closely associated with CHD risk. In the EPIC (European Prospective Investigation Into Cancer and Nutrition)-Norfolk prospective population study, 21,448 participants without diabetes or CHD between age 45 and 79 years were followed for 11.0 years. A total of 2,086 participants developed CHD during follow-up. Among individuals with low LDL-C levels (130 mg/dl had a hazard ratio (HR) for future CHD of 1.84 (95% confidence interval [CI]: 1.12 to 3.04) when compared with those with non-HDL-C levels 150 mg/dl had an HR of 1.63 (95% CI: 1.02 to 2.59) when compared with those with TG levels 5 had an HR of 2.19 (95% CI: 1.22 to 3.93) when compared with those with a TC/HDL-C ratio
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2009.07.057