Nitric oxide diffusing capacity versus spirometry in the early diagnosis of emphysema in smokers

Summary The diffusion capacity for nitric oxide (DLNO) is independent of pulmonary capillary blood volume and equals the membrane diffusing capacity. Therefore the DLNO could be more sensitive in detecting alveolar destruction than the DLCO. We measured flow-volumes curves, DLNO, DLCO, the transfer...

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Bibliographic Details
Published in:Respiratory medicine 2009-12, Vol.103 (12), p.1892-1897
Main Authors: van der Lee, I, Gietema, H.A, Zanen, P, van Klaveren, R.J, Prokop, M, Lammers, J.-W.J, van den Bosch, J.M.M
Format: Article
Language:English
Subjects:
Aged
Airway management
Biological and medical sciences
Chronic obstructive pulmonary disease, asthma
Confidence intervals
COPD
Diffusion capacity
Emphysema
Epidemiologic Methods
Humans
Hypotheses
Lungs
Male
Medical imaging
Medical sciences
Medical screening
Middle Aged
Nitric oxide
Nitric Oxide - metabolism
Pneumology
Pulmonary Diffusing Capacity - methods
Pulmonary Emphysema - diagnosis
Pulmonary Emphysema - physiopathology
Pulmonary/Respiratory
Smoking - adverse effects
Spirometry
Spirometry - methods
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Summary:Summary The diffusion capacity for nitric oxide (DLNO) is independent of pulmonary capillary blood volume and equals the membrane diffusing capacity. Therefore the DLNO could be more sensitive in detecting alveolar destruction than the DLCO. We measured flow-volumes curves, DLNO, DLCO, the transfer coefficients KNO (DLNO/VA) and KCO (DLCO/VA) and performed computed tomography (CT) scans in 263 randomly selected heavy smokers. Subjects with areas ≥1% of the total lung volume showing an attenuation
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2009.06.005