The state of the immune system in thyroidectomized rats

Disorders in the immune system manifesting in decreased weight and cellularity of lymphoid organs, decreased count of large granular lymphocytes, suppression of the immune response and metabolic activity of macrophages were observed in experimental animals 1-6 months after thyroidectomy. The intensi...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2003-02, Vol.135 (2), p.154-157
Main Authors: Bendyug, G D, Grinevich, Yu A, Khranovskaya, N N, Fil'chakov, F V, Yugrinova, L G, Kad'kalenko, A G
Format: Article
Language:English
Subjects:
Animals
Immune System - cytology
Immune System - physiology
Male
Organ Size
Rats
Rats, Wistar
Spleen - anatomy & histology
Spleen - metabolism
Thymus Gland - anatomy & histology
Thymus Gland - metabolism
Thyroidectomy
Time Factors
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Summary:Disorders in the immune system manifesting in decreased weight and cellularity of lymphoid organs, decreased count of large granular lymphocytes, suppression of the immune response and metabolic activity of macrophages were observed in experimental animals 1-6 months after thyroidectomy. The intensity of these disorders depends on the period elapsed after the surgery. These disorders can result from not only changes in the levels of the pituitary-thyroid hormones, but also disturbances in the endocrine function of the thymus in thyroidectomized animals.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1023819914926