Fasting Plasma Glucose and Incidence of Diabetes --- Implication for the Threshold for Impaired Fasting Glucose: Results from the Population-Based Omiya MA Cohort Study

Aim: In 2003, the American Diabetes Association recommended that the threshold for diagnosing impaired fasting glucose (IFG) should be lowered from 6.1 mmol/L (110 mg/dL) to 5.6 mmol/L (100 mg/dL). To discuss the diagnostic threshold for IFG, the association between fasting plasma glucose (FPG) and...

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Bibliographic Details
Published in:Journal of Atherosclerosis and Thrombosis 2010, Vol.16(6), pp.857-861
Main Authors: Kato, Masayuki, Noda, Mitsuhiko, Suga, Hiroshi, Matsumoto, Masahiko, Kanazawa, Yasunori
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Glucose - metabolism
Cohort Studies
Diabetes
Diabetes Mellitus - blood
Diabetes Mellitus - epidemiology
Fasting
Female
Humans
Impaired fasting glucose
Incidence
Japan
Male
Middle Aged
Proportional Hazards Models
Retrospective Studies
Risk
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Summary:Aim: In 2003, the American Diabetes Association recommended that the threshold for diagnosing impaired fasting glucose (IFG) should be lowered from 6.1 mmol/L (110 mg/dL) to 5.6 mmol/L (100 mg/dL). To discuss the diagnostic threshold for IFG, the association between fasting plasma glucose (FPG) and the risk of future diabetes must be known; however, data regarding this relation in the Japanese population are scarce. The aim of this study was to determine the relation between FPG and the risk of future diabetes in the Japanese general population. Methods: A retrospective cohort study was conducted using data from annual health check-ups performed in Omiya city. A total of 11,369 subjects between the ages of 40-79 years who were not dia-betic at baseline were followed for seven years. Diabetes was defined as FPG ≥126 mg/dL or self-report. Results: The incidence of diabetes increased as the baseline FPG level increased and a similar pattern was observed irrespective of sex or age. The hazard ratios compared with subjects with FPG
ISSN:1340-3478
1880-3873
DOI:10.5551/jat.1792