Different steps of sexual development are differentially regulated by the Sec8p and Exo70p exocyst subunits

Abstract In this paper we show that in Schizosaccharomyces pombe, mating-specific cell adhesion is dependent on the exocyst subunit Sec8p, but independent of the exocyst subunit Exo70p. In the absence of Exo70p, the forespore membrane does not develop properly and the leading edge protein Meu14p is...

Full description

Saved in:
Bibliographic Details
Published in:FEMS microbiology letters 2010-04, Vol.305 (1), p.71-80
Main Authors: Sharifmoghadam, Mohammad Reza, De Leon, Nagore, Hoya, Marta, Curto, María-Ángeles, Valdivieso, María-Henar
Format: Article
Language:English
Subjects:
Asci
Carrier Proteins - physiology
Cell Adhesion
Cell adhesion & migration
Cell Wall - metabolism
Cell walls
exocyst
Fungal Proteins - physiology
Gene Expression Regulation, Fungal
Mating
Microbiology
Protein Subunits - physiology
protein trafficking
Schizosaccharomyces - cytology
Schizosaccharomyces - growth & development
Schizosaccharomyces - physiology
Schizosaccharomyces pombe Proteins - physiology
sexual development
sporulation
Vesicular Transport Proteins - physiology
yeast
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract In this paper we show that in Schizosaccharomyces pombe, mating-specific cell adhesion is dependent on the exocyst subunit Sec8p, but independent of the exocyst subunit Exo70p. In the absence of Exo70p, the forespore membrane does not develop properly and the leading edge protein Meu14p is abnormally distributed. Additionally, the spindle pole body is aberrant in a significant number of exo70 Δ asci. In both the sec8-1 and the exo70 Δ mutants, the development of the spore cell wall is impaired. These results show that different steps of sexual development are differentially regulated by the exocyst and suggest the existence of exocyst subcomplexes with distinct roles in mating.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.2010.01915.x