Rhodococcus equi infection

Summary Rhodococcus equi is a veterinary pathogen that can cause substantial morbidity in patients that are immunocompromised and are occupationally and recreationally exposed to farming, livestock, and dry soil environments. Although the clinical spectrum of disease associated with R equi is broad,...

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Bibliographic Details
Published in:The Lancet infectious diseases 2010-05, Vol.10 (5), p.350-359
Main Authors: Yamshchikov, Alexandra V, Dr, Schuetz, Audrey, MD, Lyon, G Marshall, MD
Format: Article
Language:English
Subjects:
Actinomycetales Infections - complications
Actinomycetales Infections - drug therapy
Actinomycetales Infections - microbiology
Aged
Anti-Bacterial Agents - therapeutic use
Bacterial diseases
Bacterial diseases of the respiratory system
Biological and medical sciences
Human bacterial diseases
Humans
Immunocompromised Host
Immunosuppressive Agents - therapeutic use
Infectious Disease
Infectious diseases
Kidney Transplantation
Livestock
Lymphadenitis - microbiology
Male
Mediastinal Diseases - microbiology
Medical sciences
Occupational Exposure
Pneumonia, Bacterial - complications
Pneumonia, Bacterial - drug therapy
Pneumonia, Bacterial - microbiology
Rhodococcus equi - isolation & purification
Soil environment
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Summary:Summary Rhodococcus equi is a veterinary pathogen that can cause substantial morbidity in patients that are immunocompromised and are occupationally and recreationally exposed to farming, livestock, and dry soil environments. Although the clinical spectrum of disease associated with R equi is broad, pulmonary involvement is a predominant feature in most cases. We present a case of occupationally acquired R equi pneumonia and mediastinal lymphadenitis in a patient that has had a renal transplant and is in receipt of a stable immunosuppression regimen. We review the pathogenesis and clinical characteristics of infections with Rhodococcus spp, and discuss approaches to treatment of this disease entity in populations of patients who are immunocompromised.
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(10)70068-2