The potential impact of using glycated haemoglobin as the preferred diagnostic tool for detecting Type 2 diabetes mellitus

Diabet. Med. 27, 762–769 (2010) Aims  There are calls to simplify the diagnosis of Type 2 diabetes mellitus (T2DM) to reduce the burden of undiagnosed disease. Glycated haemoglobin (HbA1c) is therefore being considered as a preferred diagnostic tool to replace the need for an oral glucose tolerance...

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Bibliographic Details
Published in:Diabetic medicine 2010-07, Vol.27 (7), p.762-769
Main Authors: Mostafa, S. A., Davies, M. J., Webb, D., Gray, L. J., Srinivasan, B. T, Jarvis, J., Khunti, K.
Format: Article
Language:English
Subjects:
Adult
Aged
Anthropometry - methods
Biological and medical sciences
Biomarkers - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Diabetes. Impaired glucose tolerance
diagnostic test
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
glucose tolerance test
Glucose Tolerance Test - methods
Glycated Hemoglobin A - analysis
haemoglobin A1c protein
human
Humans
Male
Medical sciences
Middle Aged
Prevalence
Reproducibility of Results
Type 2 diabetes mellitus
United Kingdom - epidemiology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
World Health Organization
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Summary:Diabet. Med. 27, 762–769 (2010) Aims  There are calls to simplify the diagnosis of Type 2 diabetes mellitus (T2DM) to reduce the burden of undiagnosed disease. Glycated haemoglobin (HbA1c) is therefore being considered as a preferred diagnostic tool to replace the need for an oral glucose tolerance test (OGTT), considered by many as cumbersome and inconvenient. The aim of this study was to examine the potential impact of the preferred use of HbA1c as a diagnostic tool on the prevalence and phenotype of T2DM. Methods  Analysis of the Leicester Ethnic Atherosclerosis and Diabetes Risk (LEADER) cohort for previously undiagnosed individuals between 40 and 75 years of age who had OGTT, repeated if within the diabetes range, and HbA1c results. We compared the prevalence and phenotype of subjects with T2DM based on either HbA1c≥6.5% or OGTT using 1999 World Health Organization criteria. Results  From the total population of 8696, we detected 291 (3.3%) with T2DM from using an OGTT, and 502 (5.8%) had HbA1c≥6.5%. Of those diagnosed with T2DM by OGTT, 93 (1.2%) had HbA1c
ISSN:0742-3071
1464-5491
DOI:10.1111/j.1464-5491.2010.03015.x