Potential role of micro-RNAs in head and neck tumorigenesis

A new class of regulatory molecules known as microRNAs (miRNAs) is redefining our understanding of the molecular pathways associated with tumorigenesis. These miRNAs are small noncoding RNA (ncRNA) sequences with potent regulatory potential. The aberrant expression of miRNAs has been associated with...

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Bibliographic Details
Published in:Head & neck 2010-08, Vol.32 (8), p.1099-1111
Main Authors: Tran, Nham, O'Brien, Christopher J., Clark, Jonathan, Rose, Barbara
Format: Article
Language:English
Subjects:
Biological and medical sciences
biomarkers
gene regulation
Head
Head and neck
Head and Neck Neoplasms - diagnosis
Head and Neck Neoplasms - etiology
Head and Neck Neoplasms - therapy
Humans
Medical sciences
microRNAs
MicroRNAs - physiology
miRNA
Neck
non-coding RNA
Oncogenes
Otorhinolaryngology. Stomatology
RNA
Tumor suppressor genes
Tumorigenesis
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Summary:A new class of regulatory molecules known as microRNAs (miRNAs) is redefining our understanding of the molecular pathways associated with tumorigenesis. These miRNAs are small noncoding RNA (ncRNA) sequences with potent regulatory potential. The aberrant expression of miRNAs has been associated with the development of various tumors. It has been suggested that miRNAs can both regulate and act as tumor‐suppressor genes and oncogenes. Our understanding of the role of miRNAs in head and neck tumorigenesis is in its infancy. However, several recent studies have revealed extensive dysregulation of miRNA in head and neck tumors and have highlighted the potential of certain miRNAs to act as diagnostic and prognostic markers and targets for new therapeutic agents. The intent of this review is to discuss and summarize current findings that point to a significant role for miRNAs in head and neck tumorigenesis. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
ISSN:1043-3074
1097-0347
1097-0347
DOI:10.1002/hed.21356