Animal models for the assessment of novel vascular conduits

The development of an ideal small-diameter conduit for use in vascular bypass surgery has yet to be achieved. The ongoing innovation in biomaterial design generates novel conduits that require preclinical assessment in vivo, and a number of animal models have been used for this purpose. This article...

Full description

Saved in:
Bibliographic Details
Published in:Journal of vascular surgery 2010-07, Vol.52 (1), p.176-195
Main Authors: Byrom, Michael J., MBChB, Bannon, Paul G., PhD, White, Geoffrey H., FRACS, Ng, Martin K.C., PhD
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biocompatible Materials
Biological and medical sciences
Blood Vessel Prosthesis
Blood Vessel Prosthesis Implantation - instrumentation
Dogs
Emergency and intensive care: renal failure. Dialysis management
Hemodynamics
Hemostasis
Humans
Intensive care medicine
Materials Testing - methods
Medical sciences
Mice
Models, Animal
Papio
Prosthesis Design
Rabbits
Rats
Reproducibility of Results
Sheep
Species Specificity
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Swine
Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The development of an ideal small-diameter conduit for use in vascular bypass surgery has yet to be achieved. The ongoing innovation in biomaterial design generates novel conduits that require preclinical assessment in vivo, and a number of animal models have been used for this purpose. This article examines the rationale behind animal models used in the assessment of small-diameter vascular conduits encompassing the commonly used species: baboons, sheep, pigs, dogs, rabbits, and rodents. Studies on the comparative hematology for these species relative to humans are summarized, and the hydrodynamic values for common implant locations are also compared. The large- and small-animal models are then explored, highlighting the characteristics of each that determine their relative utility in the assessment of vascular conduits. Where possible, the performance of expanded polytetrafluoroethylene is given in each animal and in each location to allow direct comparisons between species. New challenges in animal modeling are outlined for the assessment of tissue-engineered graft designs. Finally, recommendations are given for the selection of animal models for the assessment of future vascular conduits.
ISSN:0741-5214
1097-6809
DOI:10.1016/j.jvs.2009.10.080