Prolonged consumption of soy or fish-oil-enriched diets differentially affects the pattern of hypothalamic neuronal activation induced by refeeding in rats

We used c-Fos immunoreactivity to estimate neuronal activation in hypothalamic feeding-regulatory areas of 3-month-old rats fed control or oil-enriched diets (soy or fish) since weaning. While no diet effect was observed in c-Fos immunoreactivity of 24-h fasted animals, the acute response to refeedi...

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Bibliographic Details
Published in:Nutritional neuroscience 2009-12, Vol.12 (6), p.242-248
Main Authors: Watanabe, Regina L.H., Andrade, Iracema S., Zemdegs, Juliane C.S., Albuquerque, Kelse T., Nascimento, Claudia M.O., Oyama, Lila M., Carmo, Maria G.T., Nogueira, Maria I., Ribeiro, Eliane B.
Format: Article
Language:English
Subjects:
Animals
APPETITE REGULATION
Body Weight
C-FOS IMMUNOREACTIVITY
Diet
Eating - physiology
Energy Intake
Fasting - physiology
Fatty Acids - analysis
FISH OIL
Fish Oils - chemistry
HYPERLIPIDIC DIET
HYPOTHALAMUS
Hypothalamus - chemistry
Hypothalamus - cytology
Hypothalamus - physiology
Immunohistochemistry
Male
Neurons - metabolism
Neurons - physiology
Organ Specificity
Proto-Oncogene Proteins c-fos - metabolism
Random Allocation
Rats
Rats, Wistar
SOY OIL
Soybean Oil - chemistry
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Summary:We used c-Fos immunoreactivity to estimate neuronal activation in hypothalamic feeding-regulatory areas of 3-month-old rats fed control or oil-enriched diets (soy or fish) since weaning. While no diet effect was observed in c-Fos immunoreactivity of 24-h fasted animals, the acute response to refeeding was modified by both hyperlipidic diets but with different patterns. Upon refeeding, control-diet rats had significantly increased c-Fos immunoreactivity only in the paraventricular hypothalamic nucleus (PVH, 142%). In soy-diet rats, refeeding with the soy diet increased c-Fos immunoreactivity in dorsomedial hypothalamic nucleus (DMH, 271%) and lateral hypothalamic area (LH, 303%). Refeeding fish-diet rats with the fish diet increased c-Fos immunoreactivity in PVH (161%), DMH (177%), VMH (81%), and ARC (127%). Compared to the fish-diet, c-Fos immunoreactivity was increased in LH by the soy-diet while it was decreased in ventromedial hypothalamic nucleus (VMH) and arcuate hypothalamic nucleus (ARC). Based on the known roles of the activated nuclei, it is suggested that, unlike the fish-diet, the soy-diet induced a potentially obesogenic profile, with high LH and low VMH/PVH activation after refeeding.
ISSN:1028-415X
1476-8305
DOI:10.1179/147683009X423472