Relation of Cardiac Troponin I Measurements at 24 and 48 Hours to Magnetic Resonance–Determined Infarct Size in Patients With ST-Elevation Myocardial Infarction

• Published in: The American journal of cardiology 2009-12, Vol.104 (11), p.1472-1477
• Main Authors: Hallén, Jonas, MD, Buser, Peter, MD, PhD, Schwitter, Jürg, MD, Petzelbauer, Peter, MD, PhD, Geudelin, Bernard, MD, Fagerland, Morten W., MSc, Jaffe, Allan S., MD, Atar, Dan, MD
• Format: Article
• Language: English
• Subjects: Aged; Angioplasty, Balloon, Coronary; Austria; Biological and medical sciences; Biomarkers - blood; Cardiology; Cardiology. Vascular system; Cardiovascular; Coronary heart disease; Electrocardiography; Female; Fibrin Fibrinogen Degradation Products - therapeutic use; Heart; Heart attacks; Heart Conduction System - physiopathology; Humans; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Minnesota; Models, Statistical; Myocardial Infarction - blood; Myocardial Infarction - diagnosis; Myocardial Infarction - physiopathology; Myocardial Infarction - therapy; Myocardial Reperfusion Injury - prevention & control; Myocarditis. Cardiomyopathies; NMR; Norway; Nuclear magnetic resonance; Peptide Fragments - therapeutic use; Predictive Value of Tests; Prognosis; Randomized Controlled Trials as Topic; Regression Analysis; Research Design; Risk Factors; Sensitivity and Specificity; Switzerland; Time Factors; Troponin I - blood; Troponin T - blood
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2009.07.019

Levels of circulating cardiac troponin I (cTnI) or T are correlated to extent of myocardial destruction after an acute myocardial infarction. Few studies analyzing this relation have employed a second-generation cTnI assay or cardiac magnetic resonance (CMR) as the imaging end point. In this post hoc study of the Efficacy of FX06 in the Prevention of Mycoardial Reperfusion Injury (F.I.R.E.) trial, we aimed at determining the correlation between single-point cTnI measurements and CMR-estimated infarct size at 5 to 7 days and 4 months after a first-time ST-elevation myocardial infarction (STEMI) and investigating whether cTnI might provide independent prognostic information regarding infarct size at 4 months even taking into account early infarct size. Two hundred twenty-seven patients with a first-time STEMI were included in F.I.R.E. All patients received primary percutaneous coronary intervention within 6 hours from onset of symptoms. cTnI was measured at 24 and 48 hours after admission. CMR was conducted within 1 week of the index event (5 to 7 days) and at 4 months. Pearson correlations (r) for infarct size and cTnI at 24 hours were r = 0.66 (5 days) and r = 0.63 (4 months) and those for cTnI at 48 hours were r = 0.67 (5 days) and r = 0.65 (4 months). In a multiple regression analysis for predicting infarct size at 4 months (n = 141), cTnI and infarct location retained an independent prognostic role even taking into account early infarct size. In conclusion, a single-point cTnI measurement taken early after a first-time STEMI is a useful marker for infarct size and might also supplement early CMR evaluation in prediction of infarct size at 4 months.