Catecholoestrogens: possible role in systemic lupus erythematosus

It is well established that risk of developing SLE is higher among women compared with men but only very little is understood about the underlying mechanisms. Oestrogen and their catechol metabolites seem to play an important role in SLE but the exact patho-aetiology remains elusive. The evidences c...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2009-11, Vol.48 (11), p.1345-1351
Main Authors: Khan, Wahid Ali, Uddin, Moin, Khan, Mohd. Wajid Ali, Chabbra, Harvinder S.
Format: Article
Language:English
Subjects:
Autoantibodies
Autoantibodies - biosynthesis
Biological and medical sciences
Catecholoestrogen
Catecholoestrogen-modified DNA
Diseases of the osteoarticular system
DNA Damage - immunology
Estrogens, Catechol - immunology
Estrogens, Catechol - physiology
Female
Humans
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - physiopathology
Medical sciences
Reactive oxygen species
Reactive Oxygen Species - metabolism
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Systemic lupus erythematosus
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Summary:It is well established that risk of developing SLE is higher among women compared with men but only very little is understood about the underlying mechanisms. Oestrogen and their catechol metabolites seem to play an important role in SLE but the exact patho-aetiology remains elusive. The evidences concerning the possibility of catecholoestrogens (CEs) in the development of SLE are very limited and preliminary. The possible mechanism involves quinone–semiquinone redox cycling of CEs to generate the free radical that can cause DNA damage. This would probably alter its immunogenicity leading to the induction and elevated levels of SLE autoantibodies cross-reacting with native DNA. The data demonstrate the possible role of CE in presenting unique neo-epitopes that might form one of the factors in induction of SLE autoantibodies. However, the role of oestrogen in immune modulation cannot be rule out as a mediator of various immune-related diseases.
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/kep168