N-terminal pro-B-type natriuretic peptide is an independent predictor of cardiovascular morbidity and mortality in the general population

Aims Natriuretic peptides including N-terminal pro-B-type natriuretic peptide (NT-proBNP) are established biomarkers in heart failure. However, their prognostic value in the general population is less well established. The purpose of our study was to investigate the prognostic properties of NT-proBN...

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Published in:European heart journal 2010-01, Vol.31 (1), p.120-127
Main Authors: Linssen, Gerard C.M., Bakker, Stephan J.L., Voors, Adriaan A., Gansevoort, Ron T., Hillege, Hans L., de Jong, Paul E., van Veldhuisen, Dirk J., Gans, Rijk O.B., de Zeeuw, Dick
Format: Article
Language:English
Subjects:
Adult
Aged
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - mortality
Cause of Death
Epidemiology
Female
Humans
Incidence
Kaplan-Meier Estimate
Male
Middle Aged
Natriuretic Peptide, Brain - metabolism
Natriuretic peptides
Netherlands - epidemiology
Peptide Fragments - metabolism
Population
Prognosis
Prospective Studies
Risk Factors
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Summary:Aims Natriuretic peptides including N-terminal pro-B-type natriuretic peptide (NT-proBNP) are established biomarkers in heart failure. However, their prognostic value in the general population is less well established. The purpose of our study was to investigate the prognostic properties of NT-proBNP for death and cardiovascular (CV) events in the general population. Methods and results In the population-based Prevention of Renal and Vascular End-stage Disease (PREVEND) study, 8383 subjects were prospectively followed for a median period of 7.5 years. There were 4181 (49.9%) males and 4202 (50.1%) females, mean age was 49.3 ± 12.7 years (range 28–75). Median NT-proBNP at baseline was 37.7 pg/mL (IQR 16.8–73.8). All-cause death occurred in 437 (5.2%) subjects and there were 557 (6.6%) CV events. Higher levels of plasma NT-proBNP were related to higher event rates. When adjusted for age, gender, and other relevant covariates, each doubling of NT-proBNP remained significantly associated with a 22% increased risk for all-cause mortality (P < 0.001) and a 16% increased risk of CV events (P < 0.001). Conclusion In this large community-based cohort, plasma NT-proBNP was a strong predictor of death and a wide range of CV events.
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehp420