Aptamers and riboswitches: perspectives in biotechnology

Aptamers are short, single stranded nucleic acids which bind a wide range of different ligands with extraordinary high binding affinity and specificity. The steadily increasing number of aptamers is accompanied by an expanding range of applications in biotechnology. We will describe new developments...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 2009-11, Vol.85 (2), p.229-236
Main Authors: Weigand, Julia E, Suess, Beatrix
Format: Article
Language:English
Subjects:
Acids
Antibodies
Aptamers, Nucleotide
Bacteria - genetics
Bacteria - metabolism
Binding sites
Biological and medical sciences
Biosensors
Biotechnology
Biotechnology - methods
Biotechnology - trends
DNA - genetics
Eukaryotic Cells - physiology
Evolution
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Regulation
Genetic Engineering - methods
Genetic Engineering - trends
Life Sciences
Ligands
Methods. Procedures. Technologies
Microbial Genetics and Genomics
Microbiology
Mini-Review
Nucleic acids
Prokaryotes
Proteins
RNA - genetics
RNA - immunology
RNA, Messenger - genetics
SELEX Aptamer Technique - trends
Sensitivity and Specificity
Various methods and equipments
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Summary:Aptamers are short, single stranded nucleic acids which bind a wide range of different ligands with extraordinary high binding affinity and specificity. The steadily increasing number of aptamers is accompanied by an expanding range of applications in biotechnology. We will describe new developments in the field including the use of aptamers for conditional gene regulation and as biosensors. In addition, we will discuss the potential of aptamers as tags to visualize RNA and protein distribution in living cells and as therapeutics. Furthermore, we will consider biotechnological applications of riboswitches for gene regulation and as drug target.
ISSN:0175-7598
1432-0614
DOI:10.1007/s00253-009-2194-2