Transport of Proteins Across the Endoplasmic Reticulum Membrane

The biosynthesis of many eukaryotic proteins requires their transport across the endoplasmic reticulum (ER) membrane. The process can be divided into two phases: (i) a targeting cycle, during which, by virtue of their signal sequences, nascent polypeptides are directed to translocation sites in the...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1992-11, Vol.258 (5084), p.931-936
Main Author: Rapoport, Tom A.
Format: Article
Language:English
Subjects:
Amino acids
Biological and medical sciences
Biological Transport
Cell membranes
Cell physiology
Electrophysiology
Endoplasmic reticulum
Endoplasmic Reticulum - ultrastructure
Eukaryotic Cells - metabolism
Frontiers in Biology: Cellular Membranes
Fundamental and applied biological sciences. Psychology
Fungal Proteins - chemistry
Fungal Proteins - genetics
Heat-Shock Proteins
Intracellular Membranes - metabolism
Membrane and intracellular transports
Membrane Glycoproteins - physiology
Membrane proteins
Membrane Proteins - chemistry
Membrane Proteins - genetics
Membrane Proteins - physiology
Membrane Transport Proteins
Molecular and cellular biology
P branes
Physiological aspects
Protein biosynthesis
Protein synthesis
Protein transport
proteins
Proteins - metabolism
Receptors
Ribonucleoproteins - physiology
Ribosomes
Ribosomes - metabolism
Saccharomyces cerevisiae Proteins
SEC Translocation Channels
Signal Recognition Particle
String theory
transport
Trolley cars
Yeasts
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Summary:The biosynthesis of many eukaryotic proteins requires their transport across the endoplasmic reticulum (ER) membrane. The process can be divided into two phases: (i) a targeting cycle, during which, by virtue of their signal sequences, nascent polypeptides are directed to translocation sites in the ER and (ii) the actual transfer of proteins across the membrane. The first phase has been well characterized, whereas the latter until recently was completely unresolved. Key components of the translocation apparatus have now been identified and it seems likely that they form a protein-conducting channel in the ER membrane. The transport process is similar to the process of protein export in bacteria.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1332192