Distribution of DNA fragment sizes after irradiation with ions

Ionizing radiation is responsible for production of double-strand breaks (DSBs) in a DNA structure. In contrast to sparsely ionizing radiation, densely ionizing radiation produces DSBs that are non-randomly distributed along the DNA molecule and can form clusters of various size. The paper discusses...

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Bibliographic Details
Published in:The European physical journal. E, Soft matter and biological physics Soft matter and biological physics, 2009-11, Vol.30 (3), p.317-324, Article 317
Main Authors: Gudowska-Nowak, E., Psonka-Antończyk, K., Weron, K., Elsässer, T., Taucher-Scholz, G.
Format: Article
Language:English
Subjects:
Bacteriophage phi X 174
Biological and Medical Physics
Biological and medical sciences
Biophysics
Chemistry
Complex Fluids and Microfluidics
Complex Systems
DNA - chemistry
DNA - genetics
DNA Fragmentation - radiation effects
DNA, Viral - chemistry
DNA, Viral - genetics
Dose-Response Relationship, Radiation
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
General and physical chemistry
Ions
Microscopy, Atomic Force
Models, Biological
Molecular biophysics
Nanotechnology
Nickel
Physical chemistry of induced reactions (with radiations, particles and ultrasonics)
Physics
Physics and Astronomy
Plasmids - chemistry
Plasmids - genetics
Polymer Sciences
Radiation chemistry
Radiation-biomolecule interaction
Radiochemistry
Regular Article
Soft and Granular Matter
Surfaces and Interfaces
Thin Films
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Summary:Ionizing radiation is responsible for production of double-strand breaks (DSBs) in a DNA structure. In contrast to sparsely ionizing radiation, densely ionizing radiation produces DSBs that are non-randomly distributed along the DNA molecule and can form clusters of various size. The paper discusses minimalistic models that describe observable patterns of fragment length in DNA segments irradiated with heavy ions and applies the formalism to interpret the recent experimental data collected by use of atomic force microscope (AFM).
ISSN:1292-8941
1292-895X
DOI:10.1140/epje/i2009-10522-7