Statin Use is Associated with a Significant Reduction in Cholesterol Content of Erythrocyte Membranes. A Novel Pleiotropic Effect?

Purpose High cholesterol content of erythrocyte membranes (CEM) levels is present in patients with acute coronary syndromes (ACS). Intraplaque hemorrhage and erythrocyte lysis contribute to the deposition of cholesterol on the atherosclerotic plaque and to plaque rupture. With the present study we a...

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Bibliographic Details
Published in:Cardiovascular drugs and therapy 2009-12, Vol.23 (6), p.471-480
Main Authors: Tziakas, Dimitrios N., Chalikias, Georgios K., Stakos, Dimitrios, Tentes, Ioannis K., Thomaidi, Adina, Chatzikyriakou, Sofia, Mitrousi, Konstantina, Kortsaris, Alexandros X., Carlos Kaski, Juan, Boudoulas, Harisios, Konstantinides, Stavros
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - drug therapy
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular system
Cholesterol - blood
Coronary Angiography
Coronary heart disease
Disorders of blood lipids. Hyperlipoproteinemia
Erythrocyte Membrane - drug effects
Heart
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic diseases
Middle Aged
Pharmacology. Drug treatments
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Summary:Purpose High cholesterol content of erythrocyte membranes (CEM) levels is present in patients with acute coronary syndromes (ACS). Intraplaque hemorrhage and erythrocyte lysis contribute to the deposition of cholesterol on the atherosclerotic plaque and to plaque rupture. With the present study we assessed the effect of statin therapy on CEM levels, a novel marker of coronary artery disease (CAD) instability during a 1-year follow-up in CAD patients. Methods 212 consecutive eligible (158 men, 62 ± 10 years) patients undergoing diagnostic coronary angiography for the assessment of angina pectoris were assessed. The study population comprised of 84 chronic stable angina (CSA) patients and 128 ACS patients. All study participants were commenced on statin treatment in equipotent doses and were followed for up to 1 year (at  − 1,  − 3,  − 6 and  − 12 months). Results Repeated measurements analysis of variance after appropriate adjustment showed a significant decrease ( p  
ISSN:0920-3206
1573-7241
DOI:10.1007/s10557-009-6202-7