Fas expression on peripheral blood lymphocytes in systemic lupus erythematosus: relation to the organ damage and lymphocytes apoptosis

Systemic lupus erythematosus (SLE) is a common autoimmune disease with complex etiology. Recently, a possible role of apoptotic cells in its pathogenesis has been suggested. This study is to evaluate the expression of Fas antigen on peripheral blood lymphocytes (PBLs) in SLE, to determine whether me...

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Bibliographic Details
Published in:Molecular biology reports 2009-11, Vol.36 (8), p.2047-2052
Main Authors: Li, Lian-Hong, Li, Wen-Xian, Wu, Ou, Zhang, Guo-Qing, Pan, Hai-Feng, Li, Xiang-Pei, Xu, Jian-Hua, Dai, Hong, Ye, Dong-Qing
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animal Anatomy
Animal Biochemistry
Apoptosis
Apoptosis - physiology
Biomedical and Life Sciences
Cellular biology
fas Receptor - biosynthesis
fas Receptor - blood
Female
Flow Cytometry
Histology
Humans
Life Sciences
Lupus
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - pathology
Lymphocytes
Lymphocytes - metabolism
Lymphocytes - pathology
Male
Middle Aged
Molecular biology
Morphology
Statistics, Nonparametric
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Summary:Systemic lupus erythematosus (SLE) is a common autoimmune disease with complex etiology. Recently, a possible role of apoptotic cells in its pathogenesis has been suggested. This study is to evaluate the expression of Fas antigen on peripheral blood lymphocytes (PBLs) in SLE, to determine whether membrane Fas (mFas) has a role in the organ damage in SLE and to explore its relationship with the early apoptosis of the PBLs in SLE. Flow cytometry was used to evaluate the expression of mFas on PBLs in 68 Chinese SLE patients and 37 healthy controls. Systemic lupus international collaborative clinics/american colleges of rheumatology damage index (SDI) scores were calculated to further estimate the relationship of the expression of mFas with disease severity. Results showed that mFas expression levels were significantly higher (P < 0.01) among SLE patients than those in healthy controls. Higher (P = 0.01) expressions of mFas were found in patients with SDI scores ≥ as compared to those with SDI scores
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-008-9415-0