Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells

ABSTRACT Sixteen heat‐killed bifidobacteria isolated from human intestine and a probiotic strain Lactobacillus GG were tested for their ability to influence IgE‐mediated degranulation of rat basophilic leukemia (RBL‐2H3) cells in vitro. The bifidobacteria suppressed IgE‐mediated degranulation of RBL...

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Published in:Microbiology and immunology 2010-01, Vol.54 (1), p.54-57
Main Authors: Harata, Gaku, He, Fang, Takahashi, Kyoko, Hosono, Akira, Kawase, Manabu, Kubota, Akira, Hiramatsu, Masaru, Kaminogawa, Shuichi
Format: Article
Language:English
Subjects:
Animals
Basophil Degranulation Test
Basophils - immunology
bifidobacteria
Bifidobacterium - physiology
Cell Line, Tumor
degranulation
Humans
IgE-mediated allergy
Immunoglobulin E - immunology
Intestines - microbiology
Lactobacillus - physiology
Leukemia, Basophilic, Acute - immunology
Leukemia, Basophilic, Acute - pathology
mast cells
Rats
Signal Transduction
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Summary:ABSTRACT Sixteen heat‐killed bifidobacteria isolated from human intestine and a probiotic strain Lactobacillus GG were tested for their ability to influence IgE‐mediated degranulation of rat basophilic leukemia (RBL‐2H3) cells in vitro. The bifidobacteria suppressed IgE‐mediated degranulation of RBL‐2H3 cells by 1.6–56.4% in a strain‐dependent manner. Bifidobacteria from healthy infants expressed high inhibitory effects on IgE‐mediated degranulation (41–55%), while those from allergic infants varied greatly in their effects against degranulation. Bifidobacteria taxonomically identified as Bifidobacterium bifidum exhibited much stronger inhibitory effects against IgE‐mediated degranulation than those taxonomically identified as B. adolescentis (P < 0.05).These results indicate that the intestinal bifidobacteria might be one of factors influencing IgE‐mediated allergic responses.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.2009.00185.x