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Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells
ABSTRACT Sixteen heat‐killed bifidobacteria isolated from human intestine and a probiotic strain Lactobacillus GG were tested for their ability to influence IgE‐mediated degranulation of rat basophilic leukemia (RBL‐2H3) cells in vitro. The bifidobacteria suppressed IgE‐mediated degranulation of RBL...
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| Published in: | Microbiology and immunology 2010-01, Vol.54 (1), p.54-57 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4555-75683c41f9e07d760b772810176507d0a2eb1991089ae5c29b4171fb0bea0c893 |
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| cites | cdi_FETCH-LOGICAL-c4555-75683c41f9e07d760b772810176507d0a2eb1991089ae5c29b4171fb0bea0c893 |
| container_end_page | 57 |
| container_issue | 1 |
| container_start_page | 54 |
| container_title | Microbiology and immunology |
| container_volume | 54 |
| creator | Harata, Gaku He, Fang Takahashi, Kyoko Hosono, Akira Kawase, Manabu Kubota, Akira Hiramatsu, Masaru Kaminogawa, Shuichi |
| description | ABSTRACT
Sixteen heat‐killed bifidobacteria isolated from human intestine and a probiotic strain Lactobacillus GG were tested for their ability to influence IgE‐mediated degranulation of rat basophilic leukemia (RBL‐2H3) cells in vitro. The bifidobacteria suppressed IgE‐mediated degranulation of RBL‐2H3 cells by 1.6–56.4% in a strain‐dependent manner. Bifidobacteria from healthy infants expressed high inhibitory effects on IgE‐mediated degranulation (41–55%), while those from allergic infants varied greatly in their effects against degranulation. Bifidobacteria taxonomically identified as Bifidobacterium bifidum exhibited much stronger inhibitory effects against IgE‐mediated degranulation than those taxonomically identified as B. adolescentis (P < 0.05).These results indicate that the intestinal bifidobacteria might be one of factors influencing IgE‐mediated allergic responses. |
| doi_str_mv | 10.1111/j.1348-0421.2009.00185.x |
| format | article |
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Sixteen heat‐killed bifidobacteria isolated from human intestine and a probiotic strain Lactobacillus GG were tested for their ability to influence IgE‐mediated degranulation of rat basophilic leukemia (RBL‐2H3) cells in vitro. The bifidobacteria suppressed IgE‐mediated degranulation of RBL‐2H3 cells by 1.6–56.4% in a strain‐dependent manner. Bifidobacteria from healthy infants expressed high inhibitory effects on IgE‐mediated degranulation (41–55%), while those from allergic infants varied greatly in their effects against degranulation. Bifidobacteria taxonomically identified as Bifidobacterium bifidum exhibited much stronger inhibitory effects against IgE‐mediated degranulation than those taxonomically identified as B. adolescentis (P < 0.05).These results indicate that the intestinal bifidobacteria might be one of factors influencing IgE‐mediated allergic responses.</description><identifier>ISSN: 0385-5600</identifier><identifier>EISSN: 1348-0421</identifier><identifier>DOI: 10.1111/j.1348-0421.2009.00185.x</identifier><identifier>PMID: 20055943</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Animals ; Basophil Degranulation Test ; Basophils - immunology ; bifidobacteria ; Bifidobacterium - physiology ; Cell Line, Tumor ; degranulation ; Humans ; IgE-mediated allergy ; Immunoglobulin E - immunology ; Intestines - microbiology ; Lactobacillus - physiology ; Leukemia, Basophilic, Acute - immunology ; Leukemia, Basophilic, Acute - pathology ; mast cells ; Rats ; Signal Transduction</subject><ispartof>Microbiology and immunology, 2010-01, Vol.54 (1), p.54-57</ispartof><rights>2009 The Societies and Blackwell Publishing Asia Pty Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4555-75683c41f9e07d760b772810176507d0a2eb1991089ae5c29b4171fb0bea0c893</citedby><cites>FETCH-LOGICAL-c4555-75683c41f9e07d760b772810176507d0a2eb1991089ae5c29b4171fb0bea0c893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20055943$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harata, Gaku</creatorcontrib><creatorcontrib>He, Fang</creatorcontrib><creatorcontrib>Takahashi, Kyoko</creatorcontrib><creatorcontrib>Hosono, Akira</creatorcontrib><creatorcontrib>Kawase, Manabu</creatorcontrib><creatorcontrib>Kubota, Akira</creatorcontrib><creatorcontrib>Hiramatsu, Masaru</creatorcontrib><creatorcontrib>Kaminogawa, Shuichi</creatorcontrib><title>Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells</title><title>Microbiology and immunology</title><addtitle>Microbiol Immunol</addtitle><description>ABSTRACT
Sixteen heat‐killed bifidobacteria isolated from human intestine and a probiotic strain Lactobacillus GG were tested for their ability to influence IgE‐mediated degranulation of rat basophilic leukemia (RBL‐2H3) cells in vitro. The bifidobacteria suppressed IgE‐mediated degranulation of RBL‐2H3 cells by 1.6–56.4% in a strain‐dependent manner. Bifidobacteria from healthy infants expressed high inhibitory effects on IgE‐mediated degranulation (41–55%), while those from allergic infants varied greatly in their effects against degranulation. Bifidobacteria taxonomically identified as Bifidobacterium bifidum exhibited much stronger inhibitory effects against IgE‐mediated degranulation than those taxonomically identified as B. adolescentis (P < 0.05).These results indicate that the intestinal bifidobacteria might be one of factors influencing IgE‐mediated allergic responses.</description><subject>Animals</subject><subject>Basophil Degranulation Test</subject><subject>Basophils - immunology</subject><subject>bifidobacteria</subject><subject>Bifidobacterium - physiology</subject><subject>Cell Line, Tumor</subject><subject>degranulation</subject><subject>Humans</subject><subject>IgE-mediated allergy</subject><subject>Immunoglobulin E - immunology</subject><subject>Intestines - microbiology</subject><subject>Lactobacillus - physiology</subject><subject>Leukemia, Basophilic, Acute - immunology</subject><subject>Leukemia, Basophilic, Acute - pathology</subject><subject>mast cells</subject><subject>Rats</subject><subject>Signal Transduction</subject><issn>0385-5600</issn><issn>1348-0421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqNkE1v1DAQhi0EokvLX0C-AYeEsR3HscSFXfVjpS2oVSuOxkkmxdtkE-xEbP89Dlv2jC-27PeZGT-EUAYpi-vTNmUiKxLIOEs5gE4BWCHT_QuyOD68JAsQhUxkDnBC3oSwBeCKF9lrchIZKXUmFuTH0jWu7ktbjejd1NEwDYPHEDDQ9cN50mHt7Ig1rfHB293U2tH1O9o31NuRljb0w0_Xuoq2OD1i5yz9cLvcJPxKfKQVtm04I68a2wZ8-7yfkvuL87vVVbL5drlefdkkVSalTJTMC1FlrNEIqlY5lCrOyoCpXMYLsBxLpjWDQluUFddlxhRrSijRQlVocUreH-oOvv81YRhN58I8gd1hPwWjhMg5yyWLyeKQrHwfgsfGDN511j8ZBmbWa7Zmtmhmi2bWa_7qNfuIvntuMpXRzBH85zMGPh8Cv12LT_9d2Fyvr-Mh4skBd2HE_RG3_tHkSihpvn-9NLf6Yqlv-Cp-6Q8dI5YV</recordid><startdate>201001</startdate><enddate>201001</enddate><creator>Harata, Gaku</creator><creator>He, Fang</creator><creator>Takahashi, Kyoko</creator><creator>Hosono, Akira</creator><creator>Kawase, Manabu</creator><creator>Kubota, Akira</creator><creator>Hiramatsu, Masaru</creator><creator>Kaminogawa, Shuichi</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201001</creationdate><title>Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells</title><author>Harata, Gaku ; He, Fang ; Takahashi, Kyoko ; Hosono, Akira ; Kawase, Manabu ; Kubota, Akira ; Hiramatsu, Masaru ; Kaminogawa, Shuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4555-75683c41f9e07d760b772810176507d0a2eb1991089ae5c29b4171fb0bea0c893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Basophil Degranulation Test</topic><topic>Basophils - immunology</topic><topic>bifidobacteria</topic><topic>Bifidobacterium - physiology</topic><topic>Cell Line, Tumor</topic><topic>degranulation</topic><topic>Humans</topic><topic>IgE-mediated allergy</topic><topic>Immunoglobulin E - immunology</topic><topic>Intestines - microbiology</topic><topic>Lactobacillus - physiology</topic><topic>Leukemia, Basophilic, Acute - immunology</topic><topic>Leukemia, Basophilic, Acute - pathology</topic><topic>mast cells</topic><topic>Rats</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harata, Gaku</creatorcontrib><creatorcontrib>He, Fang</creatorcontrib><creatorcontrib>Takahashi, Kyoko</creatorcontrib><creatorcontrib>Hosono, Akira</creatorcontrib><creatorcontrib>Kawase, Manabu</creatorcontrib><creatorcontrib>Kubota, Akira</creatorcontrib><creatorcontrib>Hiramatsu, Masaru</creatorcontrib><creatorcontrib>Kaminogawa, Shuichi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microbiology and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harata, Gaku</au><au>He, Fang</au><au>Takahashi, Kyoko</au><au>Hosono, Akira</au><au>Kawase, Manabu</au><au>Kubota, Akira</au><au>Hiramatsu, Masaru</au><au>Kaminogawa, Shuichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells</atitle><jtitle>Microbiology and immunology</jtitle><addtitle>Microbiol Immunol</addtitle><date>2010-01</date><risdate>2010</risdate><volume>54</volume><issue>1</issue><spage>54</spage><epage>57</epage><pages>54-57</pages><issn>0385-5600</issn><eissn>1348-0421</eissn><abstract>ABSTRACT
Sixteen heat‐killed bifidobacteria isolated from human intestine and a probiotic strain Lactobacillus GG were tested for their ability to influence IgE‐mediated degranulation of rat basophilic leukemia (RBL‐2H3) cells in vitro. The bifidobacteria suppressed IgE‐mediated degranulation of RBL‐2H3 cells by 1.6–56.4% in a strain‐dependent manner. Bifidobacteria from healthy infants expressed high inhibitory effects on IgE‐mediated degranulation (41–55%), while those from allergic infants varied greatly in their effects against degranulation. Bifidobacteria taxonomically identified as Bifidobacterium bifidum exhibited much stronger inhibitory effects against IgE‐mediated degranulation than those taxonomically identified as B. adolescentis (P < 0.05).These results indicate that the intestinal bifidobacteria might be one of factors influencing IgE‐mediated allergic responses.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>20055943</pmid><doi>10.1111/j.1348-0421.2009.00185.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Microbiology and immunology, 2010-01, Vol.54 (1), p.54-57 |
| issn | 0385-5600 1348-0421 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733621651 |
| source | Wiley-Blackwell Read & Publish Collection; Alma/SFX Local Collection |
| subjects | Animals Basophil Degranulation Test Basophils - immunology bifidobacteria Bifidobacterium - physiology Cell Line, Tumor degranulation Humans IgE-mediated allergy Immunoglobulin E - immunology Intestines - microbiology Lactobacillus - physiology Leukemia, Basophilic, Acute - immunology Leukemia, Basophilic, Acute - pathology mast cells Rats Signal Transduction |
| title | Bifidobacterium suppresses IgE-mediated degranulation of rat basophilic leukemia (RBL-2H3) cells |
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