Antihepatotoxic activity of debelalactone, a new oxirano-furanocoumarin from Phyllanthus debilis

The whole plant of Phyllanthus debilis (Euphorbiacae) afforded a new oxirano-furanocoumarin, characterized as 5-hydroxy-7-methoxy-furanocoumarin-9(14)-cyclohex-12(13)-oxirano-11-one (1), named as debelalactone. Debelalactone exhibited a significant antihepatotoxic activity by reducing the elevated l...

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Bibliographic Details
Published in:Journal of asian natural products research 2009-08, Vol.11 (8), p.687-692
Main Authors: Ahmed, Bahar, Khan, Shamshir, Verma, Amita, Habibullah
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - blood
Animals
antihepatotoxic activity
Aspartate Aminotransferases - blood
Biological and medical sciences
Carbon Tetrachloride - pharmacology
debelalactone
Euphorbiacae
Furocoumarins - chemistry
Furocoumarins - isolation & purification
Furocoumarins - pharmacology
General pharmacology
histopathological studies
India
Liver - drug effects
Liver - enzymology
Liver - pathology
Male
Medical sciences
Molecular Structure
Natural products
oxirano-furanocoumarin
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phyllanthus - chemistry
Phyllanthus debilis
Rats
Rats, Wistar
Rodents
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Summary:The whole plant of Phyllanthus debilis (Euphorbiacae) afforded a new oxirano-furanocoumarin, characterized as 5-hydroxy-7-methoxy-furanocoumarin-9(14)-cyclohex-12(13)-oxirano-11-one (1), named as debelalactone. Debelalactone exhibited a significant antihepatotoxic activity by reducing the elevated levels of serum enzymes such as serum glutamate oxaloacetate transaminase (SGOT) by 59.14%, serum glutamate pyruvate oxaloacetate transaminase (SGPT) by 61.84%, and alkaline phosphatase (ALP) by 85.93%; while the total protein (TP) levels were increased by 110.35%, when compared with standard drug silymarin that have decreased SGOT by 77.03%, SGPT by 69.67%, ALP by 93.18%, and increased TP levels by 100.48%, respectively, against CCl 4 -induced toxicity in Wistar rats. These biochemical observations were also supplemented by histopathological examinations of the liver sections.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020802621864