Association of toll-like receptor 3 gene polymorphism with subacute sclerosing panencephalitis

Innate immunity plays an important role in measles virus (MV) infection. MV-derived double-stranded RNA is recognized by toll-like receptor 3 (TLR3), retinoic acid-inducible protein I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). We investigated whether genes encoding these molecule...

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Bibliographic Details
Published in:Journal of neurovirology 2008, Vol.14 (6), p.486-491
Main Authors: Ishizaki, Yoshito, Takemoto, Megumi, Kira, Ryutaro, Kusuhara, Koichi, Torisu, Hiroyuki, Sakai, Yasunari, Sanefuji, Masafumi, Yukaya, Naoko, Hara, Toshiro
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
Asian People - genetics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Child
Child, Preschool
DEAD Box Protein 58
DEAD-box RNA Helicases - genetics
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Genetic Predisposition to Disease
Haplotypes
Human viral diseases
Humans
Immunology
Infectious Diseases
Male
Measles virus
Medical sciences
Neurology
Neurosciences
Polymorphism, Single Nucleotide
Receptors, Immunologic
Subacute Sclerosing Panencephalitis - genetics
Toll-Like Receptor 3 - genetics
Viral diseases
Viral diseases of the nervous system
Virology
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Summary:Innate immunity plays an important role in measles virus (MV) infection. MV-derived double-stranded RNA is recognized by toll-like receptor 3 (TLR3), retinoic acid-inducible protein I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). We investigated whether genes encoding these molecules contributed to the development of subacute sclerosing panencephalitis (SSPE) in Japanese individuals. Four single nucleotide polymorphisms (SNPs) of the three genes (TLR3 rs3775291:Leu412Phe, RIG1 rs277729 and rs9695310, and MDA5 rs4664463) were assessed in 40 SSPE patients and 84 controls. Because the TLR3 SNP showed a positive association with SSPE, three additional SNPs were subjected to haplotype analysis. The frequency of 412Phe allele of TLR3 rs3775291 in SSPE patients was significantly higher than that in controls (P=.03). In haplotype analysis of four SNPs in the TLR3 gene, the frequency of −7C/IVS3+71C/Phe412/c.1377C haplotype was significantly increased in SSPE patients (P=.006, odds ration [OR]: 2.2). TLR3 gene may confer host genetic susceptibility to SSPE in Japanese individuals.
ISSN:1355-0284
1538-2443
DOI:10.1080/13550280802298120