The Role of the Hedgehog Signaling Pathway in the Development of Basal Cell Carcinoma and Opportunities for Treatment

The hedgehog (Hh) signaling pathway plays an important role in embryogenesis across multiple species. Its activity is reduced or absent in adult organisms. However, activation of the pathway has been shown to be a factor in the development of a number of human malignancies and inhibition of the path...

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Bibliographic Details
Published in:Clinical cancer research 2010-07, Vol.16 (13), p.3335-3339
Main Authors: CARO, Ivor, LOW, Jennifer A
Format: Article
Language:English
Subjects:
Antineoplastic agents
Basal Cell Nevus Syndrome - metabolism
Biological and medical sciences
Carcinoma, Basal Cell - metabolism
Dermatology
Hedgehog Proteins - metabolism
Hedgehog Proteins - physiology
Humans
Ligands
Medical sciences
Pharmacology. Drug treatments
Receptors, G-Protein-Coupled - metabolism
Signal Transduction
Skin Neoplasms - metabolism
Smoothened Receptor
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:The hedgehog (Hh) signaling pathway plays an important role in embryogenesis across multiple species. Its activity is reduced or absent in adult organisms. However, activation of the pathway has been shown to be a factor in the development of a number of human malignancies and inhibition of the pathway is being investigated as a potential treatment for multiple cancers. The most extensively investigated and best characterized is basal cell carcinoma (BCC), which occurs in both an inherited form (basal cell nevus syndrome or Gorlin's syndrome) and a sporadic form. Sporadic BCCs are the most common human malignancy. There is recent data available on the use of a small molecule inhibitor of the pathway in BCC.
ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.ccr-09-2570