Flow Induced Dispersion Analysis Quantifies Noncovalent Interactions in Nanoliter Samples

Flow Induced Dispersion Analysis (FIDA) is presented as a new approach to characterize noncovalent interactions. The new method only requires nanoliter samples, is easy to implement, and also provides diffusivities of the free analyte and the formed complex. The technique is based on signal analysis...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Chemical Society 2010-03, Vol.132 (12), p.4070-4071
Main Authors: Jensen, Henrik, Østergaard, Jesper
Format: Article
Language:English
Subjects:
Chromatography, High Pressure Liquid
Flow Injection Analysis - methods
Microfluidic Analytical Techniques
Naphthols - chemistry
Naproxen - chemistry
Pharmaceutical Preparations - chemistry
Spectrophotometry, Ultraviolet
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Flow Induced Dispersion Analysis (FIDA) is presented as a new approach to characterize noncovalent interactions. The new method only requires nanoliter samples, is easy to implement, and also provides diffusivities of the free analyte and the formed complex. The technique is based on signal analysis of temporal variances obtained for pressure driven flows in micrometer sized fused silica capillaries.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja100484d