Toll-Like Receptor Agonists Allow Generation of Long-Lasting Antipneumococcal Humoral Immunity in Response to a Plain Polysaccharidic Vaccine

Toll-like receptors (TLRs) are considered as potential targets for vaccine adjuvants. Here, we explored the impact of TLR agonists on the B cell response to a prototypic thymus-independent (TI) antigen: a Streptococcus pneumoniae capsular polysaccharide (PS). In adult mice, all TLR agonists (and CpG...

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Bibliographic Details
Published in:The Journal of infectious diseases 2010-08, Vol.202 (3), p.470-479
Main Authors: Taillardet, Morgan, Haffar, Ghina, Mondière, Paul, Asensio, Marie-Jeanne, Pléau-Pison, Thomas, Burdin, Nicolas, Defrance, Thierry, Genestier, Laurent
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Agonists
Animals
Antibodies
Antibodies, Viral - blood
Antibody formation
Antigens
Applied microbiology
B lymphocytes
Bacteria
Biological and medical sciences
Conjugate vaccines
Fundamental and applied biological sciences. Psychology
Infectious diseases
Medical sciences
Mice
Mice, Inbred C57BL
Microbiology
Oligodeoxyribonucleotides - administration & dosage
Pneumococcal Vaccines - immunology
Polysaccharides
Polysaccharides, Bacterial - immunology
Streptococcus pneumoniae - immunology
Toll-Like Receptors - agonists
Vaccination
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:Toll-like receptors (TLRs) are considered as potential targets for vaccine adjuvants. Here, we explored the impact of TLR agonists on the B cell response to a prototypic thymus-independent (TI) antigen: a Streptococcus pneumoniae capsular polysaccharide (PS). In adult mice, all TLR agonists (and CpG oligodeoxynucleotides [ODN] in particular) enhance the PS antibody response, provided that their administration is delayed until the second day after PS vaccination. In infant mice, CpG ODN not only potentiated the PS3 antibody response but also restored responsiveness to PS3 vaccination. Moreover, the immune protection induced by the plain PS3 vaccine adjuvanted by CpG ODN was comparable to that conferred by the conjugate vaccine in terms of efficiency and longevity. CpG ODN exert their adjuvant effect by increasing the survival rate of antigen-stimulated B cells as well as the output of plasmablasts. Our results provide a rationale for broader application of polysaccharidic vaccines.
ISSN:0022-1899
1537-6613
DOI:10.1086/653739