variable plasma quercetin response to 12-week quercetin supplementation in humans

Background/Objectives: Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors. Subjects/Methods: Subjects (N=10...

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Bibliographic Details
Published in:European journal of clinical nutrition 2010-07, Vol.64 (7), p.692-697
Main Authors: Jin, F, Nieman, D.C, Shanely, R.A, Knab, A.M, Austin, M.D, Sha, W
Format: Article
Language:English
Subjects:
631/92/436/1729
692/700/459/1994
Adolescent
Adult
Age
Aged
Aged, 80 and over
Bioavailability
Blood
blood plasma
Body Constitution
Body mass index
Body size
Clinical Nutrition
Demographics
Diet
Dietary Supplements
dose response
Dose-Response Relationship, Drug
Double-Blind Method
Epidemiology
Female
Food groups
Food intake
Gender
gender differences
Health aspects
human nutrition
Humans
Internal Medicine
lifestyle
Male
Medicine
Medicine & Public Health
men
Metabolic Diseases
Metabolism
Middle Aged
nutrition physiology
Nutrition research
original-article
Physical fitness
Physiological aspects
phytochemicals
Placebos
Plant Extracts - administration & dosage
Plant Extracts - blood
Plant Extracts - pharmacology
Plasma
Public Health
Quercetin
Quercetin - administration & dosage
Quercetin - blood
Quercetin - pharmacology
randomized clinical trials
sociodemographic characteristics
women
Young Adult
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Description
Summary:Background/Objectives: Quercetin supplementation results in a variable plasma quercetin response in humans. The purpose of this study was to determine whether this variance is related to gender, age, body mass index (BMI), and other demographic and lifestyle factors. Subjects/Methods: Subjects (N=1002, ages 18–85 years, 60% female and 40% male) were recruited from the community and randomized to one of three groups, with supplements administered using double-blinded procedures: Q-500 (500 mg/day), Q-1000 (1000 mg/day), or placebo. Subjects ingested two soft chew supplements twice daily during the 12-week study. Fasting blood samples were obtained pre- and post-study, analyzed for plasma quercetin, and then compared between and within groups by gender, age group (
ISSN:0954-3007
1476-5640
DOI:10.1038/ejcn.2010.91