Prospective study on dialysis patients after total parathyroidectomy without autoimplant

• Published in: Nephrology (Carlton, Vic.) Vic.), 2010-06, Vol.15 (4), p.441-447
• Main Authors: CHAN, HILDA WAI-HAN, CHU, KWOK-HONG, FUNG, SAMUEL KA-SHUN, TANG, HON-LOK, LEE, WILLIAM, CHEUK, AU, YIM, KA-FAI, TONG, MATTHEW KWOK-LUNG, LEE, KAM-CHEONG
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biomarkers - blood; Biopsy; Bone Density; Bone Diseases, Metabolic - blood; Bone Diseases, Metabolic - etiology; Bone Diseases, Metabolic - pathology; Bone Diseases, Metabolic - prevention & control; Calcium - blood; China; Chronic Disease; densitometry; Female; Femur Neck - pathology; Humans; Hyperparathyroidism, Secondary - blood; Hyperparathyroidism, Secondary - etiology; Hyperparathyroidism, Secondary - pathology; Hyperparathyroidism, Secondary - surgery; Kidney Diseases - blood; Kidney Diseases - complications; Kidney Diseases - therapy; Lumbar Vertebrae - pathology; Male; Middle Aged; parathyroid hormone; Parathyroid Hormone - blood; Parathyroidectomy; Peritoneal Dialysis; Phosphates - blood; Prospective Studies; Renal Dialysis; renal osteodystrophy; secondary hyperparathyroidism; Time Factors; Treatment Outcome
• ISSN: 1320-5358; 1440-1797
• DOI: 10.1111/j.1440-1797.2009.01257.x

Aim:  Secondary hyperparathyroidism is common in chronic kidney disease. When medical treatment fails, subtotal or total parathyroidectomy with autoimplant is done but both are associated with a high recurrence rate. The third surgical strategy is total parathyroidectomy without autoimplant. We evaluate the outcomes of patients who had total parathyroidectomy with no autoimplant. Methods:  Thirteen patients who had total parathyroidectomy without autoimplant were prospectively studied from 1998–2002. Intact parathyroid hormone, biochemistry and bone mineral densities were measured at baseline and serially. All patients had bone biopsies done preoperatively and seven had repeat bone biopsies at a mean of 37.7 months postoperatively. Histomorphometric studies were done for all bone biopsies. Patients were observed for fractures. Results:  Five patients were on haemodialysis and eight on peritoneal dialysis. Mean duration of follow up was 68 months. Postoperatively, mean intact parathyroid hormone decreased precipitously and remained within or just above normal. Mean serum calcium phosphate product decreased and remained normal. Out of seven patients who had repeat bone biopsies, two showed reversal of hyperparathyroid bone disease to normal, two had mild hyperparathyroidism, while three had adynamic bone disease. One patient with adynamic bone disease subsequently developed biochemical recurrence of hyperparathyroidism. Serial bone densitometry showed remarkable improvement. There was no fracture. Conclusion:  In the studied series of total parathyroidectomy without autoimplant, adynamic bone disease occurred in three out of seven repeat bone biopsies while improvement occurred in the rest. Bone mineral density was much improved and there was no fracture. Total parathyroidectomy without autoimplantation was effective for improvement of bone mineral density in dialysis patients. Although no fracture was documented, the authors still found a certain patients (3 out of 7) with adynamic bone disease at repeated bone biopsies.