Bioactive Isoflavones from Dalbergia vacciniifolia (Fabaceae)

Three new 5-dehydroxy isoflavone compounds, 6,2′-dimethoxy-7,4′-dihydroxyisoflavone (1), 6,2′,4′-trimethoxy-7-hydroxyisoflavone (2), and 6,2′,4′,5′-tetramethoxy-7-O-[β–D-apiofuranosyl-(1→6)-β–D-glucopyranoside] isoflavone (3), along with a known isoflavone, 6,2′,4′,5′-tetramethoxy-7-hydroxyisoflavon...

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Bibliographic Details
Published in:Natural product communications 2010-06, Vol.5 (6), p.903-906
Main Authors: Innocent, Ester, Magadula, Joseph J., Kihampa, Charles, Heydenreich, Matthias
Format: Article
Language:English
Subjects:
Dalbergia - chemistry
Isoflavones - chemistry
Molecular Structure
Plant Stems - chemistry
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Summary:Three new 5-dehydroxy isoflavone compounds, 6,2′-dimethoxy-7,4′-dihydroxyisoflavone (1), 6,2′,4′-trimethoxy-7-hydroxyisoflavone (2), and 6,2′,4′,5′-tetramethoxy-7-O-[β–D-apiofuranosyl-(1→6)-β–D-glucopyranoside] isoflavone (3), along with a known isoflavone, 6,2′,4′,5′-tetramethoxy-7-hydroxyisoflavone (4), were isolated from the ethanolic extract of Dalbergia vacciniifolia Vatke. Their structures were established by spectroscopic techniques including one- and two-dimension NMR. Compound 1 showed mild cytotoxic activity against brine shrimp larvae with a LC50 value of 266 μg/mL
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1000500617