Supplementation of ascorbic acid and alpha-tocopherol is useful to preventing bone loss linked to oxidative stress in elderly

Objective To determine the effect of ascorbic acid and alpha-tocopherol on oxidative stress and bone mineral density (BMD) in elderly people. Design A double-blind, controlled clinical assay was carried out in a sample of 90 elderly subjects divided into three age-paired random groups with 30 subjec...

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Bibliographic Details
Published in:The Journal of nutrition, health & aging health & aging, 2010-06, Vol.14 (6), p.467-472
Main Authors: Ruiz-Ramos, M., Alberto Vargas, L., Fortoul Van Der Goes, T. I., Cervantes-Sandoval, A., Mendoza-Nú`nez, V. M.
Format: Article
Language:English
Subjects:
Aged
Aging
alpha-Tocopherol - pharmacology
Antioxidants - pharmacology
Ascorbic Acid - pharmacology
Biological and medical sciences
Bone Density - drug effects
Bone Density - physiology
Dietary Supplements
Diseases of the osteoarticular system
Double-Blind Method
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Geriatrics/Gerontology
Glutathione Peroxidase - blood
Humans
JNHA: Clinical Trials and Aging
Male
Medical sciences
Medicine
Medicine & Public Health
Neurosciences
Nutrition
Osteoporosis - prevention & control
Osteoporosis. Osteomalacia. Paget disease
Oxidative Stress - drug effects
Primary Care Medicine
Quality of Life Research
Superoxide Dismutase - blood
Thiobarbituric Acid Reactive Substances - metabolism
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Objective To determine the effect of ascorbic acid and alpha-tocopherol on oxidative stress and bone mineral density (BMD) in elderly people. Design A double-blind, controlled clinical assay was carried out in a sample of 90 elderly subjects divided into three age-paired random groups with 30 subjects in each group. Group Tx0 received placebo, group Tx1 received 500 mg of ascorbic acid and 400 IU of alpha-tocopherol, whereas group Tx2 received 1,000 mg of ascorbic acid and 400 IU of alpha-tocopherol, for a 12-month period. Measurements We measured thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), superoxide dismutase (SOD), and glutation peroxidase (GPx); BMD was obtained on DXA of hip and spine before and after the 12-month treatment period with supplementation of vitamins C and E. Results We found a positive correlation between hip-BMD and SOD (r = 0.298, p
ISSN:1279-7707
1760-4788
DOI:10.1007/s12603-010-0099-5