Effects of magnesium on postprandial serum lipid responses in healthy human subjects

Postprandial hyperlipidaemia has been recognised to be a risk factor for atherosclerosis development. Epidemiological and animal studies have shown that Mg intake is inversely associated with some risk factors of atherosclerosis, including lipid metabolism. The present study was performed to determi...

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Bibliographic Details
Published in:British journal of nutrition 2010-02, Vol.103 (4), p.469-472
Main Authors: Kishimoto, Yoshimi, Tani, Mariko, Uto-Kondo, Harumi, Saita, Emi, Iizuka, Maki, Sone, Hirohito, Yokota, Kuninobu, Kondo, Kazuo
Format: Article
Language:English
Subjects:
Adult
Apolipoprotein B-48 - blood
atherosclerosis
Atherosclerosis - prevention & control
Biological and medical sciences
blood lipids
Butter
Cholesterol - blood
chylomicrons
Chylomicrons - metabolism
Cross-Over Studies
Diet
Dietary Fats - administration & dosage
dietary mineral supplements
Dietary minerals
Dietary Supplements
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
health status
Humans
hyperlipidemia
Hypolipidemic Agents - pharmacology
Hypolipidemic Agents - therapeutic use
Ingestion
Lipids
Lipids - blood
Lipoproteins - blood
Magnesium
Magnesium - administration & dosage
Magnesium - pharmacology
Magnesium - therapeutic use
magnesium chloride
Magnesium Chloride - administration & dosage
Magnesium Chloride - pharmacology
Male
Micronutrients - administration & dosage
Micronutrients - pharmacology
Micronutrients - therapeutic use
nutrition assessment
Nutrition research
nutritional status
Postprandial hyperlipidaemia
Postprandial Period
postprandial state
Reference Values
Remnant lipoprotein
Risk factors
Salt lakes
TAG
triacylglycerols
Triglycerides - blood
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Postprandial hyperlipidaemia has been recognised to be a risk factor for atherosclerosis development. Epidemiological and animal studies have shown that Mg intake is inversely associated with some risk factors of atherosclerosis, including lipid metabolism. The present study was performed to determine the effects of Mg supplementation on postprandial responses in serum lipid levels. We used bittern (Nigari, in Japanese), a natural MgCl2 solution from sea or salt lake water, for Mg supplementation. In a two-way, randomised, crossover study, sixteen healthy male volunteers consumed 30 g butter with or without 5 ml bittern containing 500 mg of Mg. Fasting and postprandial blood samples were taken 2, 3, 4 and 6 h after ingestion. Postprandial lipid responses were evaluated by serum TAG, chylomicron TAG, apo-B48, remnant-like particle cholesterol (RLP-C) and NEFA concentrations. We found that the serum and the chylomicron TAG responses after the fat load were reduced and delayed by Mg supplementation. The concentrations of apo-B48 (P 
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114509992716