HIV-associated oral plasmablastic lymphoma and role of adherence to highly active antiretroviral therapy

Plasmablastic lymphoma (PBL) is an HIV-associated non-Hodgkin's lymphoma that primarily affects the oral cavity. We describe the case of an HIV patient with a lesion in the maxilla that lasted four months. He was diagnosed with PBL and received highly active antiretroviral therapy as well as ch...

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Bibliographic Details
Published in:International journal of STD & AIDS 2010-01, Vol.21 (1), p.68-70
Main Authors: Francischini, E, Martins, F M, Braz-Silva, P H, Magalhães, M H C G, Ortega, K L
Format: Article
Language:English
Subjects:
Adult
AIDS/HIV
Anti-Retroviral Agents - therapeutic use
Antiretroviral Therapy, Highly Active
Biological and medical sciences
General aspects
Hematologic and hematopoietic diseases
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, AIDS-Related - drug therapy
Lymphoma, AIDS-Related - pathology
Male
Maxillary Neoplasms - drug therapy
Maxillary Neoplasms - pathology
Medical sciences
Medication Adherence
Mouth - pathology
Mouth Neoplasms - drug therapy
Mouth Neoplasms - pathology
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - prevention & control
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Description
Summary:Plasmablastic lymphoma (PBL) is an HIV-associated non-Hodgkin's lymphoma that primarily affects the oral cavity. We describe the case of an HIV patient with a lesion in the maxilla that lasted four months. He was diagnosed with PBL and received highly active antiretroviral therapy as well as chemotherapy and local radiotherapy. The lesion regressed after the third cycle of chemotherapy. The patient interrupted antiretroviral treatment and the lesion recurred. The immune reconstitution secondary to the use of antiretroviral therapy seems to participate in the regression of PBL and maintains the remission of the tumour, but it might not be enough to prevent the development of PBL.
ISSN:0956-4624
1758-1052
DOI:10.1258/ijsa.2008.008476