Cofilin immunolabelling correlates with depth of invasion in gastrointestinal endocrine cell tumors

Gastrointestinal endocrine cell tumors are a heterogeneous population of lesions believed to arise from neuroendocrine cells of the gastrointestinal mucosa. The current classification of these tumors is based on tumor size, microscopic features and clinical evidence of metastasis. Although diagnosti...

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Bibliographic Details
Published in:Acta histochemica 2010, Vol.112 (1), p.101-106
Main Authors: Yan, Benedict, Yap, Celestial T., Wang, Shi, Lee, Chi Kuen, Koh, Shiuan, Omar, Mohd Feroz, Salto-Tellez, Manuel, Kumarasinghe, Marian Priyanthi
Format: Article
Language:English
Subjects:
Actin Depolymerizing Factors - metabolism
Adult
Aged
Biomarkers, Tumor - analysis
Carcinoma - metabolism
Carcinoma - pathology
Cofilin
Endocrine Gland Neoplasms - metabolism
Endocrine Gland Neoplasms - pathology
Enteroendocrine Cells - metabolism
Enteroendocrine Cells - pathology
Female
Gastrointestinal endocrine cell tumor
Humans
Immunohistochemistry
Male
Middle Aged
Rectal Neoplasms - metabolism
Rectal Neoplasms - pathology
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
Young Adult
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Summary:Gastrointestinal endocrine cell tumors are a heterogeneous population of lesions believed to arise from neuroendocrine cells of the gastrointestinal mucosa. The current classification of these tumors is based on tumor size, microscopic features and clinical evidence of metastasis. Although diagnostic categories generally correlate with prognosis, molecular prognostic markers will be clinically useful adjuncts. Cofilin has been implicated in tumor invasion, and its immunolocalisation was studied in gastrointestinal endocrine cell tumors. The immunolocalisation of cofilin was studied by immunohistochemistry in 34 formalin-fixed, paraffin wax-embedded gastrointestinal endocrine cell tumors using a tissue microarray platform. A significant correlation was found between high cofilin immunolabelling and the depth of invasion ( p
ISSN:0065-1281
1618-0372
DOI:10.1016/j.acthis.2008.07.007