Relationship between symptoms rated with the positive and negative syndrome scale and brain measures in schizophrenia

The Positive and Negative Syndrome Scale (PANSS) was used to rate clinical symptoms in 42 inpatients with schizophrenia before they were examined by computed tomography. Significantly higher mean size of lateral and third ventricles, and higher mean cortical atrophy were found in schizophrenic patie...

Full description

Saved in:
Bibliographic Details
Published in:Psychiatry research 1992-10, Vol.44 (1), p.55-62
Main Authors: d'Amato, Thierry, Rochet, Thierry, Dalery, Jean, Laurent, Annie, Chauchat, Jean-Hugues, Terra, Jean-Louis, Marie-Cardine, Michel
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Arousal - physiology
Atrophy
Biological and medical sciences
Brain - pathology
Cerebral Cortex - pathology
Cerebral Ventricles - pathology
Computed tomography
cortical atrophy
Delusions - diagnosis
Delusions - psychology
Female
Hallucinations - diagnosis
Hallucinations - psychology
Humans
Male
Medical sciences
Neurocognitive Disorders - diagnosis
Neurocognitive Disorders - psychology
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia - diagnosis
Schizophrenic Psychology
symptoms
Tomography, X-Ray Computed
ventricle-brain ratio
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Positive and Negative Syndrome Scale (PANSS) was used to rate clinical symptoms in 42 inpatients with schizophrenia before they were examined by computed tomography. Significantly higher mean size of lateral and third ventricles, and higher mean cortical atrophy were found in schizophrenic patients compared with healthy control subjects. Ventricular enlargement and cortical atrophy were significantly related to low scores on the Composite subscale of the PANSS. Positive correlations were observed mainly with negative items such as blunted affect, emotional withdrawal, difficulties in abstract thinking, passive- apathetic social withdrawal, and lack of spontaneity of conversation. Additional positive correlations were observed with two items from the General Psychopathology subscale (mannerisms and disorientation). Inverse correlations were found with most positive items. These results suggest a relationship between brain structural abnormalities and the symptomatology of schizophrenia recorded with PANSS.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(92)90069-F