High-concentration cultivation of Lactococcus cremoris in a cell-recycle reactor

High‐cell concentration cultivation of Lactococcus cremoris, a homofermentative lactic acid producer, in a cell‐recycle fermentor is described. Cross‐flow filtration allowing continuous removal of the inhibitory metabollte, the influence of dilution rate on growth was investigated in total or partia...

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Bibliographic Details
Published in:Biotechnology and bioengineering 1991-04, Vol.37 (8), p.746-754
Main Authors: Bibal, Bernard, Vayssier, Yves, Goma, Gérard, Pareilleux, Alain
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
cell-recycle fermentor
cross-flow filtration
dairy starters
fermenters
Fundamental and applied biological sciences. Psychology
high cell concentration cultures
Lactococcus cremoris
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
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Summary:High‐cell concentration cultivation of Lactococcus cremoris, a homofermentative lactic acid producer, in a cell‐recycle fermentor is described. Cross‐flow filtration allowing continuous removal of the inhibitory metabollte, the influence of dilution rate on growth was investigated in total or partial cell‐recycle cultures. The dependence of growth characteristics on operating conditions was identified and quantified using lactose as the carbon source. Growth kinetics could be described by both lactate removal efficiency and nutrient availability. Based on physiological observations, biomass and lactic acid productivities were predicted in partial cell‐recycle cultures.
ISSN:0006-3592
1097-0290
DOI:10.1002/bit.260370809