Natural history of arteriovenous malformations: analysis of non-radically treated patients

The natural history of cerebral arteriovenous malformations (AVMs) was studied in 115 patients with untreated or incompletely obliterated AVM. Sixty-six patients had histories of hemorrhage, 20 had seizures, 18 had progressive ischemic neurologic deficits and 8 had headache. Three patients had no sy...

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Bibliographic Details
Published in:Journal of clinical neuroscience 1998-03, Vol.5, p.26-29
Main Authors: Yamane, Fumitaka, Takeshita, Mikihiko, Izawa, Masahiro, Kagawa, Mizuo, Sato, Kazuei, Takakura, Kintomo
Format: Article
Language:English
Subjects:
arteriovenous malformation
natural history
rebleeding
risk of hemorrhage
venous drainage
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Summary:The natural history of cerebral arteriovenous malformations (AVMs) was studied in 115 patients with untreated or incompletely obliterated AVM. Sixty-six patients had histories of hemorrhage, 20 had seizures, 18 had progressive ischemic neurologic deficits and 8 had headache. Three patients had no symptoms attributable to the AVM. Twenty-seven (23%) AVMs rebled or newly bled and the cumulative bleeding or rebleeding rate was 72.5% (4.2% per year). The cumulative bleeding rate of the neurologic deficit group, however, was significantly lower than the cumulative rebleeding rate of the hemorrhagic group ( P < 0.05) and that of the seizure group ( P < 0.05). No significant differences were found in regard to the initial clinical manifestations. The cumulative survival rate was 84% and the average mortality rate was 1.4% per year. Fifty patients (43%) were below 90 in Karnofsky's Index at the end of the follow-up period and the average morbidity rate was 6.0% per year.
ISSN:0967-5868
1532-2653
DOI:10.1016/S0967-5868(98)90006-6