No reflow-like pattern in intramyocardial coronary artery suggests myocardial ischemia in patients with hypertrophic cardiomyopathy

• Published in: Journal of cardiology 2008-08, Vol.52 (1), p.7-16
• Main Authors: Kim, Woo-Shik, MD, Minagoe, Shinichi, MD, FJCC, Mizukami, Naoko, RCS, Zhou, Xiaoyan, MD, Yoshinaga, Keiichiro, MD, Takasaki, Kunitsugu, MD, Yuasa, Toshinori, MD, Kihara, Koichi, MD, Hamasaki, Shuichi, MD, FJCC, Otsuji, Yutaka, MD, FJCC, Kisanuki, Akira, MD, FJCC, Tei, Chuwa, MD, FJCC
• Format: Article
• Language: English
• Subjects: Adult; Cardiomyopathies; Cardiomyopathy, Hypertrophic - complications; Cardiomyopathy, Hypertrophic - diagnostic imaging; Cardiovascular; Coronary microcirculation; Coronary Vessels - diagnostic imaging; Echocardiography; Echocardiography, Doppler; Female; Humans; Hypertrophic; Male; Middle Aged; Myocardial Ischemia - diagnostic imaging; Radionuclide Imaging; Radiopharmaceuticals; Thallium Radioisotopes
• ISSN: 0914-5087; 1876-4738
• DOI: 10.1016/j.jjcc.2008.04.004

Abstract Background and purpose To evaluate intramyocardial coronary flow velocity pattern by transthoracic Doppler echocardiography and its clinical significance in patients with hypertrophic cardiomyopathy (HCM). Methods and results In 48 patients with HCM who had angiographically normal coronary artery, coronary flow velocity in the left anterior descending coronary artery (LAD) and intramyocardial coronary artery (IMCA) derived from LAD were evaluated using transthoracic Doppler echocardiography. Two clearly different flow patterns in the IMCA were observed in patients with HCM. Twenty-seven HCM patients (group A) had slow deceleration slope in the IMCA flow (average diastolic deceleration time, 989 ± 338; range, 585–1680) and the remaining 21 patients (group B) had steep deceleration slope with diastolic deceleration time