Effect of Transplantation of Peripheral Blood Mononuclears Obtained Using Granulocytic Colony-Stimulating Factor and Hyaluronidase on Regeneration of Hemopoietic Tissue during Myelosuppression

The mechanisms of hemopoiesis recovery after transplantation of peripheral blood mononuclears obtained using granulocytic CSF and granulocytic CSF in combination with hyaluronidase were studied on the model of cytostatic myelosuppression. It was found that regeneration of the hemopoietic tissue resu...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2009-07, Vol.148 (1), p.120-125
Main Authors: Dygai, A. M, Zyuz'kov, G. N, Zhdanov, V. V, Simanina, E. V, Stavrova, L. A, Udut, E. V, Khrichkova, T. Yu, Minakova, M. Yu, Ermakova, N. N, Firsova, T. V
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Bone Marrow - drug effects
Bone Marrow - pathology
Cell Biology
Cell Technologies in Biology and Medicine (Translated from Kletochnye Tekhnologii v Biologii i Meditsine)
Cell Transplantation
Fluorouracil - administration & dosage
Granulocyte Colony-Stimulating Factor - pharmacology
granulocytic colony-stimulating factor
hyaluronoglucosaminidase
Hyaluronoglucosaminidase - pharmacology
Internal Medicine
Laboratory Medicine
Male
Mice
Monocytes - cytology
Monocytes - drug effects
myelosuppression
Pathology
progenitor cells
transplantation
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Summary:The mechanisms of hemopoiesis recovery after transplantation of peripheral blood mononuclears obtained using granulocytic CSF and granulocytic CSF in combination with hyaluronidase were studied on the model of cytostatic myelosuppression. It was found that regeneration of the hemopoietic tissue resulted from an increase in the pool of erythroid and granulomonocytic precursors and in their functional activity. The increase in the count of fibroblast precursors in the bone marrow, higher production of hemopoietins by adherent myelokaryocytes, and an increase in the level of humoral factors in the serum were detected after injection of the transplants. A higher therapeutic efficiency of cell material obtained after combined use of granulocytic CSF and hyaluronidase was shown.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0655-3