Leptin as an Immunocorrecting Agent during Normal Pregnancy

Experiments were performed with leptin in doses observed during pregnancy. We studied the effect of leptin on expression of membrane molecules and cytokine production by peripheral blood mononuclear cells from women. Leptin increased the expression of HLA-DR on T lymphocytes, stimulated the producti...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2009-07, Vol.148 (1), p.75-78
Main Authors: Orlova, E. G, Shirshev, S. V
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
cytokines
Cytokines - biosynthesis
Female
Humans
In Vitro Techniques
Internal Medicine
Laboratory Medicine
leptin
Leptin - administration & dosage
natural killer cells
NKT cells
Pathology
pregnancy
Pregnancy - immunology
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Summary:Experiments were performed with leptin in doses observed during pregnancy. We studied the effect of leptin on expression of membrane molecules and cytokine production by peripheral blood mononuclear cells from women. Leptin increased the expression of HLA-DR on T lymphocytes, stimulated the production of TNF-α and IL-6, and did not affect secretion of IL-2, IL-4, and IL-10 by mononuclear leukocytes. Leptin in a dose comparable to that during the 1st trimester of pregnancy increased the percentage of NK cells with membrane CD16 and CD56, stimulated the production of IFN-α by mononuclear leukocytes, and did not modulate the number of CD16⁺56⁺NKT cells. Treatment with leptin in a dose for the second-third trimesters of pregnancy was followed by a decrease in the percentage of CD16⁺56⁺NKT cells and increase in the number of NKT cells expressing CD16 and CD56. Our results indicate that leptin play an important role in the regulation of membrane molecule expression and cytokine production by mononuclear leukocytes.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0636-6