Effect of Cell Therapy on Recovery of Cognitive Functions in Rats during the Delayed Period after Brain Injury

We studied the effect of systemic transplantation of human stem cells from various tissues on cognitive functions of the brain in rats during the delayed period after experimental brain injury. Stem cells were shown to increase the efficacy of medical treatment with metabolic and symptomatic drugs f...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2009-07, Vol.148 (1), p.140-147
Main Authors: Roshal, L. M., Tzyb, A. F., Pavlova, L. N., Soushkevitch, G. N., Semenova, J. B., Javoronkov, L. P., Kolganova, O. I., Konoplyannikov, A. G., Shevchuk, A. S., Yujakov, V. V., Karaseva, O. V., Ivanova, T. F., Chernyshova, T. A., Konoplyannikova, O. A., Bandurko, L. N., Marey, M. V., Sukhikh, G. T.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Brain Injuries - psychology
Cell Biology
Cell Technologies in Biology and Medicine
Cell Transplantation
Cognition
Internal Medicine
Laboratory Medicine
Male
Pathology
Rats
Rats, Wistar
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Summary:We studied the effect of systemic transplantation of human stem cells from various tissues on cognitive functions of the brain in rats during the delayed period after experimental brain injury. Stem cells were shown to increase the efficacy of medical treatment with metabolic and symptomatic drugs for recovery of cognitive functions. They accelerated the formation of the conditioned defense response. Fetal neural stem cells had a stronger effect on some parameters of cognitive function 2 months after brain injury. The efficacy of bone marrow mesenchymal stem cells from adult humans or fetuses was higher 3 months after brain injury.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0642-8